In this section
@article{Savariraj:2021:10.1021/acssensors.1c00370,
author = {Savariraj, AD and Salih, A and Alam, F and Elsherif, M and AlQattan, B and Khan, AA and Yetisen, AK and Butt, H},
doi = {10.1021/acssensors.1c00370},
journal = {ACS Sensors},
pages = {2046--2076},
title = {Ophthalmic sensors and drug delivery},
url = {http://dx.doi.org/10.1021/acssensors.1c00370},
volume = {6},
year = {2021}
}
TY - JOUR
AB - Advances in multifunctional materials and technologies have allowed contact lenses to serve as wearable devices for continuous monitoring of physiological parameters and delivering drugs for ocular diseases. Since the tear fluids comprise a library of biomarkers, direct measurement of different parameters such as concentration of glucose, urea, proteins, nitrite, and chloride ions, intraocular pressure (IOP), corneal temperature, and pH can be carried out non-invasively using contact lens sensors. Microfluidic contact lens sensor based colorimetric sensing and liquid control mechanisms enable the wearers to perform self-examinations at home using smartphones. Furthermore, drug-laden contact lenses have emerged as delivery platforms using a low dosage of drugs with extended residence time and increased ocular bioavailability. This review provides an overview of contact lenses for ocular diagnostics and drug delivery applications. The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed. The potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery systems, have also been discussed.
AU - Savariraj,AD
AU - Salih,A
AU - Alam,F
AU - Elsherif,M
AU - AlQattan,B
AU - Khan,AA
AU - Yetisen,AK
AU - Butt,H
DO - 10.1021/acssensors.1c00370
EP - 2076
PY - 2021///
SN - 2379-3694
SP - 2046
TI - Ophthalmic sensors and drug delivery
T2 - ACS Sensors
UR - http://dx.doi.org/10.1021/acssensors.1c00370
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000668374500005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://pubs.acs.org/doi/10.1021/acssensors.1c00370
UR - http://hdl.handle.net/10044/1/91344
VL - 6
ER -