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BibTex format

@article{Liu:2021:10.1016/j.actbio.2021.03.064,
author = {Liu, Q and Tian, J and Tian, Y and Sun, Q and Sun, D and Liu, D and Wang, F and Xu, H and Ying, G and Wang, J and Yetisen, AK and Jiang, N},
doi = {10.1016/j.actbio.2021.03.064},
journal = {Acta Biomaterialia},
pages = {287--297},
title = {Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy},
url = {http://dx.doi.org/10.1016/j.actbio.2021.03.064},
volume = {127},
year = {2021}
}
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TY  - JOUR
AB  - Organic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared (NIR-I) window. However, their applications in the second near-infrared (NIR-II) window are still limited primarily due to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) is created as a molecularly engineered thiophene donor unit with high QYs to the redshift. Thiophene insertion initiates substantial redshifts of the absorbance as compared to its counterparts in which iodine is introduced. The fluorescent molecule can be triggered by an NIR laser with a single wavelength, thereby producing emission in the NIR-II windows. Single NIR laser-triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and the chemotherapeutic drug docetaxel (DTX) by using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen QY (ΦΔ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics. After intravenous administration of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor showed a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the combination of photodynamic therapy (PDT) and photothermic therapy (PTT).
AU  - Liu,Q
AU  - Tian,J
AU  - Tian,Y
AU  - Sun,Q
AU  - Sun,D
AU  - Liu,D
AU  - Wang,F
AU  - Xu,H
AU  - Ying,G
AU  - Wang,J
AU  - Yetisen,AK
AU  - Jiang,N
DO  - 10.1016/j.actbio.2021.03.064
EP  - 297
PY  - 2021///
SN  - 1742-7061
SP  - 287
TI  - Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy
T2  - Acta Biomaterialia
UR  - http://dx.doi.org/10.1016/j.actbio.2021.03.064
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000653434900009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S174270612100221X?via%3Dihub
VL  - 127
ER  -
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