BibTex format
@article{Litvinukova:2020:10.1038/s41586-020-2797-4,
author = {Litvinukova, M and Talavera-Lopez, C and Maatz, H and Reichart, D and Worth, CL and Lindberg, EL and Kanda, M and Polanski, K and Heinig, M and Lee, M and Nadelmann, ER and Roberts, K and Tuck, L and Fasouli, ES and DeLaughter, DM and McDonough, B and Wakimoto, H and Gorham, JM and Samari, S and Mahbubani, KT and Saeb-Parsy, K and Patone, G and Boyle, JJ and Zhang, H and Zhang, H and Viveiros, A and Oudit, GY and Bayraktar, OA and Seidman, JG and Seidman, CE and Noseda, M and Hubner, N and Teichmann, SA},
doi = {10.1038/s41586-020-2797-4},
journal = {Nature},
pages = {466--472},
title = {Cells of the adult human heart},
url = {http://dx.doi.org/10.1038/s41586-020-2797-4},
volume = {588},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Cardiovascular disease is the leading cause of death worldwide. Advanced insights into disease mechanisms and therapeutic strategies require deeper understanding of the healthy heart’s molecular processes. Knowledge of the full repertoire of cardiac cells and their gene expression profiles is a fundamental first step in this endeavor. Here, using state-of-the-art analyses of large-scale single-cell and nuclei transcriptomes, we characterise six anatomical adult heart regions. Our results highlight the cellular heterogeneity of cardiomyocytes, pericytes, and fibroblasts, revealing distinct atrial and ventricular subsets with diverse developmental origins and specialized properties. We define the complexity of the cardiac vasculature and its changes along the arterio-venous axis. In the immune compartment we identify cardiac resident macrophages with inflammatory and protective transcriptional signatures. Further, inference of cell-cell interactions highlight different macrophage-fibroblast-cardiomyocyte networks between atria and ventricles that are distinct from skeletal muscle. Our human cardiac cell atlas improves our understanding of the human heart and provides a healthy reference for future studies.
AU - Litvinukova,M
AU - Talavera-Lopez,C
AU - Maatz,H
AU - Reichart,D
AU - Worth,CL
AU - Lindberg,EL
AU - Kanda,M
AU - Polanski,K
AU - Heinig,M
AU - Lee,M
AU - Nadelmann,ER
AU - Roberts,K
AU - Tuck,L
AU - Fasouli,ES
AU - DeLaughter,DM
AU - McDonough,B
AU - Wakimoto,H
AU - Gorham,JM
AU - Samari,S
AU - Mahbubani,KT
AU - Saeb-Parsy,K
AU - Patone,G
AU - Boyle,JJ
AU - Zhang,H
AU - Zhang,H
AU - Viveiros,A
AU - Oudit,GY
AU - Bayraktar,OA
AU - Seidman,JG
AU - Seidman,CE
AU - Noseda,M
AU - Hubner,N
AU - Teichmann,SA
DO - 10.1038/s41586-020-2797-4
EP - 472
PY - 2020///
SN - 0028-0836
SP - 466
TI - Cells of the adult human heart
T2 - Nature
UR - http://dx.doi.org/10.1038/s41586-020-2797-4
UR - https://www.nature.com/articles/s41586-020-2797-4
UR - http://hdl.handle.net/10044/1/83008
VL - 588
ER -
