BibTex format
@article{Wang:2016:10.1126/scitranslmed.aai8336,
author = {Wang, Q and Yang, H and Liu, X and Dai, L and Ma, T and Qi, J and Wong, G and Peng, R and Liu, S and Li, J and Li, S and Song, J and Liu, J and He, J and Yuan, H and Xiong, Y and Liao, Y and Li, J and Yang, J and Tong, Z and Griffin, BD and Bi, Y and Liang, M and Xu, X and Qin, C and Cheng, G and Zhang, X and Wang, P and Qiu, X and Kobinger, G and Shi, Y and Yan, J and Gao, GF},
doi = {10.1126/scitranslmed.aai8336},
journal = {Science Translational Medicine},
title = {Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus},
url = {http://dx.doi.org/10.1126/scitranslmed.aai8336},
volume = {8},
year = {2016}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - The 2015–2016 outbreak of Zika virus (ZIKV) disease has affected many countries and is a major public health concern. ZIKV is associated with fetal microcephaly and neurological complications, and countermeasures are needed to treat and prevent ZIKV infection. We report the isolation of 13 specific human monoclonal antibodies from a single patient infected with ZIKV. Two of the isolated antibodies (Z23 and Z3L1) demonstrated potent ZIKV-specific neutralization in vitro without binding or neutralizing activity against strains 1 to 4 of dengue virus, the closest relative to ZIKV. These two antibodies provided postexposure protection to mice in vivo. Structural studies revealed that Z23 and Z3L1 bound to tertiary epitopes in envelope protein domain I, II, or III, indicating potential targets for ZIKV-specific therapy. Our results suggest the potential of antibody-based therapeutics and provide a structure-based rationale for the design of future ZIKV-specific vaccines.
AU - Wang,Q
AU - Yang,H
AU - Liu,X
AU - Dai,L
AU - Ma,T
AU - Qi,J
AU - Wong,G
AU - Peng,R
AU - Liu,S
AU - Li,J
AU - Li,S
AU - Song,J
AU - Liu,J
AU - He,J
AU - Yuan,H
AU - Xiong,Y
AU - Liao,Y
AU - Li,J
AU - Yang,J
AU - Tong,Z
AU - Griffin,BD
AU - Bi,Y
AU - Liang,M
AU - Xu,X
AU - Qin,C
AU - Cheng,G
AU - Zhang,X
AU - Wang,P
AU - Qiu,X
AU - Kobinger,G
AU - Shi,Y
AU - Yan,J
AU - Gao,GF
DO - 10.1126/scitranslmed.aai8336
PY - 2016///
SN - 1946-6234
TI - Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus
T2 - Science Translational Medicine
UR - http://dx.doi.org/10.1126/scitranslmed.aai8336
VL - 8
ER -
