In this section
The Network aims to promote multi-disciplinary approaches to address challenging vaccine-related questions. This page contains a curated list of publications that highlight high-impact and collaborative approaches.
@article{Blagborough:2013:10.1038/ncomms2840,
author = {Blagborough, AM and Churcher, TS and Upton, LM and Ghani, AC and Gething, PW and Sinden, RE},
doi = {10.1038/ncomms2840},
journal = {Nature Communications},
title = {Transmission-blocking interventions eliminate malaria from laboratory populations},
url = {http://dx.doi.org/10.1038/ncomms2840},
volume = {4},
year = {2013}
}
TY - JOUR
AB - Transmission-blocking interventions aim to reduce the prevalence of infection in endemic communities by targeting Plasmodium within the insect host. Although many studies have reported the successful reduction of infection in the mosquito vector, direct evidence that there is an onward reduction in infection in the vertebrate host is lacking. Here we report the first experiments using a population, transmission-based study of Plasmodium berghei in Anopheles stephensi to assess the impact of a transmission-blocking drug upon both insect and host populations over multiple transmission cycles. We demonstrate that the selected transmission-blocking intervention, which inhibits transmission from vertebrate to insect by only 32%, reduces the basic reproduction number of the parasite by 20%, and in our model system can eliminate Plasmodium from mosquito and mouse populations at low transmission intensities. These findings clearly demonstrate that use of transmission-blocking interventions alone can eliminate Plasmodium from a vertebrate population, and have significant implications for the future design and implementation of transmission-blocking interventions within the field.
AU - Blagborough,AM
AU - Churcher,TS
AU - Upton,LM
AU - Ghani,AC
AU - Gething,PW
AU - Sinden,RE
DO - 10.1038/ncomms2840
PY - 2013///
SN - 2041-1723
TI - Transmission-blocking interventions eliminate malaria from laboratory populations
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms2840
UR - http://hdl.handle.net/10044/1/32874
VL - 4
ER -
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