In this section
@article{Graham:2023:10.1002/alz.12934,
author = {Graham, NSN and Cole, JH and Bourke, NJ and Schott, JM and Sharp, DJ},
doi = {10.1002/alz.12934},
journal = {Alzheimer's and Dementia},
pages = {3065--3077},
title = {Distinct patterns of neurodegeneration after TBI and in Alzheimer's disease},
url = {http://dx.doi.org/10.1002/alz.12934},
volume = {19},
year = {2023}
}
TY - JOUR
AB - IntroductionTraumatic brain injury (TBI) is a dementia risk factor, with Alzheimer's disease (AD) more common following injury. Patterns of neurodegeneration produced by TBI can be compared to AD and aging using volumetric MRI.MethodsA total of 55 patients after moderate to severe TBI (median age 40), 45 with AD (median age 69), and 61 healthy volunteers underwent magnetic resonance imaging over 2 years. Atrophy patterns were compared.ResultsAD patients had markedly lower baseline volumes. TBI was associated with increased white matter (WM) atrophy, particularly involving corticospinal tracts and callosum, whereas AD rates were increased across white and gray matter (GM). Subcortical WM loss was shared in AD/TBI, but deep WM atrophy was TBI-specific and cortical atrophy AD-specific. Post-TBI atrophy patterns were distinct from aging, which resembled AD.DiscussionPost-traumatic neurodegeneration 1.9–4.0 years (median) following moderate-severe TBI is distinct from aging/AD, predominantly involving central WM. This likely reflects distributions of axonal injury, a neurodegeneration trigger.HighlightsWe compared patterns of brain atrophy longitudinally after moderate to severe TBI in late-onset AD and healthy aging.Patients after TBI had abnormal brain atrophy involving the corpus callosum and other WM tracts, including corticospinal tracts, in a pattern that was specific and distinct from AD and aging.This pattern is reminiscent of axonal injury following TBI, and atrophy rates were predicted by the extent of axonal injury on diffusion tensor imaging, supporting a relationship between early axonal damage and chronic neurodegeneration.
AU - Graham,NSN
AU - Cole,JH
AU - Bourke,NJ
AU - Schott,JM
AU - Sharp,DJ
DO - 10.1002/alz.12934
EP - 3077
PY - 2023///
SN - 1552-5260
SP - 3065
TI - Distinct patterns of neurodegeneration after TBI and in Alzheimer's disease
T2 - Alzheimer's and Dementia
UR - http://dx.doi.org/10.1002/alz.12934
UR - https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12934
UR - http://hdl.handle.net/10044/1/101508
VL - 19
ER -
Established in 2017 by its principal funder the Medical Research Council, in partnership with Alzheimer's Society and Alzheimer’s Research UK, The UK Dementia Research Institute (UK DRI) is the UK’s leading biomedical research institute dedicated to neurodegenerative diseases.
