In this section
@article{Mallas:2021:brain/awaa380,
author = {Mallas, E-J and De, Simoni S and Scott, G and Jolly, A and Hampshire, A and Li, L and Bourke, N and Roberts, S and Gorgoraptis, N and Sharp, D},
doi = {brain/awaa380},
journal = {Brain: a journal of neurology},
pages = {114--127},
title = {Abnormal dorsal attention network activation in memory impairment after traumatic brain injury},
url = {http://dx.doi.org/10.1093/brain/awaa380},
volume = {144},
year = {2021}
}
TY - JOUR
AB - Memory impairment is a common, disabling effect of traumatic brain injury. In healthy individuals, successful memory encoding is associated with activation of the dorsal attention network as well as suppression of the default mode network. Here, in traumatic brain injurypatients we examined whether: i) impairments in memory encoding are associated with abnormal brain activation in these networks; ii) whether changes in this brain activity predict subsequent memory retrieval; and iii) whether abnormal white matter integrity underpinningfunctional networks is associated with impaired subsequent memory. 35 patients with moderate-severetraumatic brain injury aged 23-65 years (74% males) in the post-acute/chronic phase after injury and 16 healthy controls underwent functional MRI during performance of an abstract image memory encoding task. Diffusion tensor imaging was used to assess structural abnormalities across patient groups compared to 28 age-matched healthy controls. Successful memory encoding across all participants was associated with activation of the dorsal attention network, the ventral visual stream and medial temporal lobes. Decreased activation was seen in the default mode network. Patients with preserved episodic memory demonstrated increased activation in areas of the dorsal attention network.Patients with impaired memory showed increased left anterior prefrontal activity. White matter microstructure underpinning connectivity between core nodes of the encoding networks was significantly reduced in patients with memory impairment. Our results show for the first time that patients with impaired episodic memory show abnormal activation of key nodes within the dorsal attention network and regions regulating default mode network activity during encoding. Successful encoding was associated with an opposite direction of signal
AU - Mallas,E-J
AU - De,Simoni S
AU - Scott,G
AU - Jolly,A
AU - Hampshire,A
AU - Li,L
AU - Bourke,N
AU - Roberts,S
AU - Gorgoraptis,N
AU - Sharp,D
DO - brain/awaa380
EP - 127
PY - 2021///
SN - 0006-8950
SP - 114
TI - Abnormal dorsal attention network activation in memory impairment after traumatic brain injury
T2 - Brain: a journal of neurology
UR - http://dx.doi.org/10.1093/brain/awaa380
UR - https://academic.oup.com/brain/article/144/1/114/6050087
UR - http://hdl.handle.net/10044/1/83390
VL - 144
ER -
Established in 2017 by its principal funder the Medical Research Council, in partnership with Alzheimer's Society and Alzheimer’s Research UK, The UK Dementia Research Institute (UK DRI) is the UK’s leading biomedical research institute dedicated to neurodegenerative diseases.
