In this section
@article{Kahan:2021:10.1039/D0CB00205D,
author = {Kahan, R and Worm, D and Vieira, de Castro G and Ng, C and Barnard, A},
doi = {10.1039/D0CB00205D},
journal = {RSC Chemical Biology},
pages = {387--409},
title = {Modulators of protein–protein interactions as antimicrobial agents},
url = {http://dx.doi.org/10.1039/D0CB00205D},
volume = {2},
year = {2021}
}
TY - JOUR
AB - Protein–Protein interactions (PPIs) are involved in a myriad of cellular processes in all living organisms and the modulation of PPIs is already under investigation for the development of new drugs targeting cancers, autoimmune diseases and viruses. PPIs are also involved in the regulation of vital functions in bacteria and, therefore, targeting bacterial PPIs offers an attractive strategy for the development of antibiotics with novel modes of action. The latter are urgently needed to tackle multidrug-resistant and multidrug-tolerant bacteria. In this review, we describe recent developments in the modulation of PPIs in pathogenic bacteria for antibiotic development, including advanced small molecule and peptide inhibitors acting on bacterial PPIs involved in division, replication and transcription, outer membrane protein biogenesis, with an additional focus on toxin–antitoxin systems as upcoming drug targets.
AU - Kahan,R
AU - Worm,D
AU - Vieira,de Castro G
AU - Ng,C
AU - Barnard,A
DO - 10.1039/D0CB00205D
EP - 409
PY - 2021///
SN - 2633-0679
SP - 387
TI - Modulators of protein–protein interactions as antimicrobial agents
T2 - RSC Chemical Biology
UR - http://dx.doi.org/10.1039/D0CB00205D
UR - https://pubs.rsc.org/en/content/articlelanding/2021/CB/D0CB00205D#!divAbstract
UR - http://hdl.handle.net/10044/1/87503
VL - 2
ER -
Dr Anna Barnard
Wellcome Trust Sir Henry Dale Fellow
Department of Chemistry
Imperial College London
Wood Lane
London W12 0BZ
a.barnard@imperial.ac.uk
Tel: +44 (0)20 7594 8551