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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Broedel:2018:10.1038/s41589-018-0012-9,
author = {Broedel, AK and Isalan, M},
doi = {10.1038/s41589-018-0012-9},
journal = {Nature Chemical Biology},
pages = {328--329},
title = {Trp-ing upon new repressors},
url = {http://dx.doi.org/10.1038/s41589-018-0012-9},
volume = {14},
year = {2018}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Bioengineers have used directed evolution to generate a new family of synthetic transcription factors based on the tryptophan repressor. The evolved repressor family enables researchers to build new gene circuits for biomedical applications.
AU  - Broedel,AK
AU  - Isalan,M
DO  - 10.1038/s41589-018-0012-9
EP  - 329
PY  - 2018///
SN  - 1552-4450
SP  - 328
TI  - Trp-ing upon new repressors
T2  - Nature Chemical Biology
UR  - http://dx.doi.org/10.1038/s41589-018-0012-9
UR  - http://hdl.handle.net/10044/1/56731
VL  - 14
ER  -

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