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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Wintle:2017:10.7554/eLife.30247,
author = {Wintle, BC and Boehm, CR and Rhodes, C and Molloy, JC and Millett, P and Adam, L and Breitling, R and Carlson, R and Casagrande, R and Dando, M and Doubleday, R and Drexler, E and Edwards, B and Ellis, T and Evans, NG and Hammond, R and Haseloff, J and Kahl, L and Kuiken, T and Lichman, BR and Matthewman, CA and Napier, JA and Oheigeartaigh, SS and Patron, NJ and Perello, E and Shapira, P and Tait, J and Takano, E and Sutherland, WJ},
doi = {10.7554/eLife.30247},
journal = {eLife},
title = {A transatlantic perspective on 20 emerging issues in biological engineering},
url = {http://dx.doi.org/10.7554/eLife.30247},
volume = {6},
year = {2017}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Advances in biological engineering are likely to have substantial impacts on global society. To explorethese potential impacts we ran a horizon scanning exercise to capture a range of perspectives on the opportunitiesand risks presented by biological engineering. We first identified 70 potential issues, and then used an iterativeprocess to prioritise 20 issues that we considered to be emerging, to have potential global impact, and to berelatively unknown outside the field of biological engineering. The issues identified may be of interest toresearchers, businesses and policy makers in sectors such as health, energy, agriculture and the environment.
AU  - Wintle,BC
AU  - Boehm,CR
AU  - Rhodes,C
AU  - Molloy,JC
AU  - Millett,P
AU  - Adam,L
AU  - Breitling,R
AU  - Carlson,R
AU  - Casagrande,R
AU  - Dando,M
AU  - Doubleday,R
AU  - Drexler,E
AU  - Edwards,B
AU  - Ellis,T
AU  - Evans,NG
AU  - Hammond,R
AU  - Haseloff,J
AU  - Kahl,L
AU  - Kuiken,T
AU  - Lichman,BR
AU  - Matthewman,CA
AU  - Napier,JA
AU  - Oheigeartaigh,SS
AU  - Patron,NJ
AU  - Perello,E
AU  - Shapira,P
AU  - Tait,J
AU  - Takano,E
AU  - Sutherland,WJ
DO  - 10.7554/eLife.30247
PY  - 2017///
SN  - 2050-084X
TI  - A transatlantic perspective on 20 emerging issues in biological engineering
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.30247
UR  - http://hdl.handle.net/10044/1/54710
VL  - 6
ER  -