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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Park:2017:10.1016/j.tibtech.2017.10.013,
author = {Park, YK and Nicaud, JM and Ledesma, Amaro R},
doi = {10.1016/j.tibtech.2017.10.013},
journal = {Trends in Biotechnology},
pages = {304--317},
title = {The engineering potential of Rhodosporidium toruloides as a workhorse for biotechnological applications},
url = {http://dx.doi.org/10.1016/j.tibtech.2017.10.013},
volume = {36},
year = {2017}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Moving our society towards a bioeconomy requires efficient and sustainable microbial production of chemicals and fuels. Rhodotorula (Rhodosporidium) toruloides is a yeast that naturally synthesizes substantial amounts of specialty chemicals and has been recently engineered to (i) enhance its natural production of lipids and carotenoids, and (ii) produce novel industrially relevant compounds. The use of R. toruloides by companies and research groups has exponentially increased in recent years as a result of recent improvements in genetic engineering techniques and the availability of multiomics information on its genome and metabolism. This review focuses on recent engineering approaches in R. toruloides for bioproduction and explores its potential as a biotechnological chassis.
AU  - Park,YK
AU  - Nicaud,JM
AU  - Ledesma,Amaro R
DO  - 10.1016/j.tibtech.2017.10.013
EP  - 317
PY  - 2017///
SN  - 0167-7799
SP  - 304
TI  - The engineering potential of Rhodosporidium toruloides as a workhorse for biotechnological applications
T2  - Trends in Biotechnology
UR  - http://dx.doi.org/10.1016/j.tibtech.2017.10.013
UR  - http://hdl.handle.net/10044/1/53422
VL  - 36
ER  -