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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Liu:2016:10.1002/chem.201602482,
author = {Liu, Z and Yoshihara, A and Kelly, C and Heap, JT and Marqvorsen, MH and Jenkinson, SF and Wormald, MR and Otero, JM and Estévez, A and Kato, A and Fleet, GW and Estévez, RJ and Izumori, K},
doi = {10.1002/chem.201602482},
journal = {Chemistry},
pages = {12557--12565},
title = {6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology},
url = {http://dx.doi.org/10.1002/chem.201602482},
volume = {22},
year = {2016}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In the search for alternative non-metabolizable inducers in the l-rhamnose promoter system, the synthesis of fifteen 6-deoxyhexoses from l-rhamnose demonstrates the value of synergy between biotechnology and chemistry. The readily available 2,3-acetonide of rhamnonolactone allows inversion of configuration at C4 and/or C5 of rhamnose to give 6-deoxy-d-allose, 6-deoxy-d-gulose and 6-deoxy-l-talose. Highly crystalline 3,5-benzylidene rhamnonolactone gives easy access to l-quinovose (6-deoxy-l-glucose), l-olivose and rhamnose analogue with C2 azido, amino and acetamido substituents. Electrophilic fluorination of rhamnal gives a mixture of 2-deoxy-2-fluoro-l-rhamnose and 2-deoxy-2-fluoro-l-quinovose. Biotechnology provides access to 6-deoxy-l-altrose and 1-deoxy-l-fructose.
AU  - Liu,Z
AU  - Yoshihara,A
AU  - Kelly,C
AU  - Heap,JT
AU  - Marqvorsen,MH
AU  - Jenkinson,SF
AU  - Wormald,MR
AU  - Otero,JM
AU  - Estévez,A
AU  - Kato,A
AU  - Fleet,GW
AU  - Estévez,RJ
AU  - Izumori,K
DO  - 10.1002/chem.201602482
EP  - 12565
PY  - 2016///
SN  - 1521-3765
SP  - 12557
TI  - 6-Deoxyhexoses from l-Rhamnose in the Search for Inducers of the Rhamnose Operon: Synergy of Chemistry and Biotechnology
T2  - Chemistry
UR  - http://dx.doi.org/10.1002/chem.201602482
UR  - http://hdl.handle.net/10044/1/38665
VL  - 22
ER  -