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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Trusch:2015:10.1074/jbc.M115.680686,
author = {Trusch, F and Matena, A and Vuk, M and Koerver, L and Knaevelsrud, H and Freemont, PS and Meyer, H and Bayer, P},
doi = {10.1074/jbc.M115.680686},
journal = {Journal of Biological Chemistry},
pages = {29414--29427},
title = {The N-terminal region of the ubiquitin regulatory x (UBX) domain-containing Protein 1 (UBXD1) modulates interdomain communication within the valosin-containing Protein p97},
url = {http://dx.doi.org/10.1074/jbc.M115.680686},
volume = {290},
year = {2015}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Trusch,F
AU  - Matena,A
AU  - Vuk,M
AU  - Koerver,L
AU  - Knaevelsrud,H
AU  - Freemont,PS
AU  - Meyer,H
AU  - Bayer,P
DO  - 10.1074/jbc.M115.680686
EP  - 29427
PY  - 2015///
SN  - 1083-351X
SP  - 29414
TI  - The N-terminal region of the ubiquitin regulatory x (UBX) domain-containing Protein 1 (UBXD1) modulates interdomain communication within the valosin-containing Protein p97
T2  - Journal of Biological Chemistry
UR  - http://dx.doi.org/10.1074/jbc.M115.680686
UR  - http://hdl.handle.net/10044/1/31696
VL  - 290
ER  -