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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Kopniczky:2015:10.1109/TBCAS.2015.2451707,
author = {Kopniczky, M and moore, S and freemont, P},
doi = {10.1109/TBCAS.2015.2451707},
journal = {IEEE Transactions on Biomedical Circuits and Systems},
pages = {485--496},
title = {Multilevel regulation and translational switches in synthetic biology},
url = {http://dx.doi.org/10.1109/TBCAS.2015.2451707},
volume = {9},
year = {2015}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In contrast to the versatility of regulatory mechanisms in natural systems, synthetic genetic circuits have been so far predominantly composed of transcriptionally regulated modules. This is about to change as the repertoire of foundational tools for post-transcriptional regulation is quickly expanding. We provide an overview of the different types of translational regulators: protein, small molecule and RNA responsive and we describe the new emerging circuit designs utilizing these tools. There are several advantages of achieving multilevel regulation via translational switches and it is likely that such designs will have the greatest and earliest impact in mammalian synthetic biology for regenerative medicine and gene therapy applications.
AU  - Kopniczky,M
AU  - moore,S
AU  - freemont,P
DO  - 10.1109/TBCAS.2015.2451707
EP  - 496
PY  - 2015///
SN  - 1940-9990
SP  - 485
TI  - Multilevel regulation and translational switches in synthetic biology
T2  - IEEE Transactions on Biomedical Circuits and Systems
UR  - http://dx.doi.org/10.1109/TBCAS.2015.2451707
UR  - http://hdl.handle.net/10044/1/24561
VL  - 9
ER  -