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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Brucoli:2013:10.1021/jm4001852,
author = {Brucoli, F and Hawkins, RM and James, CH and Jackson, PJM and Wells, G and Jenkins, TC and Ellis, T and Kotecha, M and Hochhauser, D and Hartley, JA and Howard, PW and Thurston, DE},
doi = {10.1021/jm4001852},
journal = {JOURNAL OF MEDICINAL CHEMISTRY},
pages = {6339--6351},
title = {An Extended Pyrrolobenzodiazepine-Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site},
url = {http://dx.doi.org/10.1021/jm4001852},
volume = {56},
year = {2013}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Brucoli,F
AU  - Hawkins,RM
AU  - James,CH
AU  - Jackson,PJM
AU  - Wells,G
AU  - Jenkins,TC
AU  - Ellis,T
AU  - Kotecha,M
AU  - Hochhauser,D
AU  - Hartley,JA
AU  - Howard,PW
AU  - Thurston,DE
DO  - 10.1021/jm4001852
EP  - 6351
PY  - 2013///
SN  - 0022-2623
SP  - 6339
TI  - An Extended Pyrrolobenzodiazepine-Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site
T2  - JOURNAL OF MEDICINAL CHEMISTRY
UR  - http://dx.doi.org/10.1021/jm4001852
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000323593400006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
VL  - 56
ER  -