In this section

Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Murray:2020:10.1016/j.joule.2020.09.014,
author = {Murray, JW and Rutherford, AW and Nixon, PJ},
doi = {10.1016/j.joule.2020.09.014},
journal = {Joule},
pages = {2082--2084},
title = {Photosystem II in a state of disassembly},
url = {http://dx.doi.org/10.1016/j.joule.2020.09.014},
volume = {4},
year = {2020}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The light-driven oxidation of water to oxygen characteristic of oxygenic photosynthesis is catalyzed by a redox-active manganese/calcium cluster embedded in the Photosystem II (PSII) complex. How the cluster is assembled during the biogenesis and repair of PSII is unclear. Cryo-electron microscopy data have now provided new insights into the structure of a PSII complex lacking the cluster and have identified features that might be important for delivery and stabilization of Mn during assembly.
AU  - Murray,JW
AU  - Rutherford,AW
AU  - Nixon,PJ
DO  - 10.1016/j.joule.2020.09.014
EP  - 2084
PY  - 2020///
SN  - 2542-4351
SP  - 2082
TI  - Photosystem II in a state of disassembly
T2  - Joule
UR  - http://dx.doi.org/10.1016/j.joule.2020.09.014
UR  - http://hdl.handle.net/10044/1/83906
VL  - 4
ER  -