In this section

Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Keck:2021:10.1111/1751-7915.13682,
author = {Keck, FD and Polizzi, K},
doi = {10.1111/1751-7915.13682},
journal = {Microbial Biotechnology},
pages = {26--30},
title = {Microbial interventions are an easier alternative to engineer higher organisms},
url = {http://dx.doi.org/10.1111/1751-7915.13682},
volume = {14},
year = {2021}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Advances in synthetic biology have made microbes easier to engineer than ever before. However, synthetic biology in animals and plants has lagged behind. Since it is now known that the phenotype of higher organisms depends largely on their microbiota, we propose that this is an easier route to achieving synthetic biology applications in these organisms.
AU  - Keck,FD
AU  - Polizzi,K
DO  - 10.1111/1751-7915.13682
EP  - 30
PY  - 2021///
SN  - 1751-7907
SP  - 26
TI  - Microbial interventions are an easier alternative to engineer higher organisms
T2  - Microbial Biotechnology
UR  - http://dx.doi.org/10.1111/1751-7915.13682
UR  - https://sfamjournals.onlinelibrary.wiley.com/doi/10.1111/1751-7915.13682
UR  - http://hdl.handle.net/10044/1/84475
VL  - 14
ER  -