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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Price:2020:10.1111/jeb.13693,
author = {Price, TAR and Windbichler, N and Unckless, RL and Sutter, A and Runge, J-N and Ross, PA and Pomiankowski, A and Nuckolls, NL and Montchamp-Moreau, C and Mideo, N and Martin, OY and Manser, A and Legros, M and Larracuente, AM and Holman, L and Godwin, J and Gemmell, N and Courret, C and Buchman, A and Barrett, LG and Lindholm, AK},
doi = {10.1111/jeb.13693},
journal = {JOURNAL OF EVOLUTIONARY BIOLOGY},
pages = {1345--1360},
title = {Resistance to natural and synthetic gene drive systems},
url = {http://dx.doi.org/10.1111/jeb.13693},
volume = {33},
year = {2020}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Price,TAR
AU  - Windbichler,N
AU  - Unckless,RL
AU  - Sutter,A
AU  - Runge,J-N
AU  - Ross,PA
AU  - Pomiankowski,A
AU  - Nuckolls,NL
AU  - Montchamp-Moreau,C
AU  - Mideo,N
AU  - Martin,OY
AU  - Manser,A
AU  - Legros,M
AU  - Larracuente,AM
AU  - Holman,L
AU  - Godwin,J
AU  - Gemmell,N
AU  - Courret,C
AU  - Buchman,A
AU  - Barrett,LG
AU  - Lindholm,AK
DO  - 10.1111/jeb.13693
EP  - 1360
PY  - 2020///
SN  - 1010-061X
SP  - 1345
TI  - Resistance to natural and synthetic gene drive systems
T2  - JOURNAL OF EVOLUTIONARY BIOLOGY
UR  - http://dx.doi.org/10.1111/jeb.13693
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000572161100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
VL  - 33
ER  -