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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Wang:2020:10.1016/j.biortech.2020.123707,
author = {Wang, J and Ledesma-Amaro, R and Wei, Y and Ji, B and Ji, X-J},
doi = {10.1016/j.biortech.2020.123707},
journal = {Bioresource Technology},
pages = {1--11},
title = {Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica -A Review},
url = {http://dx.doi.org/10.1016/j.biortech.2020.123707},
volume = {313},
year = {2020}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Current energy security and climate change policies encourage the development and utilization of bioenergy. Oleaginous yeasts provide a particularly attractive platform for the sustainable production of biofuels and industrial chemicals due to their ability to accumulate high amounts of lipids. In particular, microbial lipids in the form of triacylglycerides (TAGs) produced from renewable feedstocks have attracted considerable attention because they can be directly used in the production of biodiesel and oleochemicals analogous to petrochemicals. As an oleaginous yeast that is generally regarded as safe, Yarrowia lipolytica has been extensively studied, with large amounts of data on its lipid metabolism, genetic tools, and genome sequencing and annotation. In this review, we highlight the newest strategies for increasing lipid accumulation using metabolic engineering and summarize the research advances on the overaccumulation of lipids in Y. lipolytica. Finally, perspectives for future engineering approaches are proposed.
AU  - Wang,J
AU  - Ledesma-Amaro,R
AU  - Wei,Y
AU  - Ji,B
AU  - Ji,X-J
DO  - 10.1016/j.biortech.2020.123707
EP  - 11
PY  - 2020///
SN  - 0960-8524
SP  - 1
TI  - Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica -A Review
T2  - Bioresource Technology
UR  - http://dx.doi.org/10.1016/j.biortech.2020.123707
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000550773600018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0960852420309792?via%3Dihub
UR  - http://hdl.handle.net/10044/1/81038
VL  - 313
ER  -