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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Moore:2020:10.1021/acssynbio.0c00177,
author = {Moore, SJ and Lai, H-E and Kelwick, RJR and Chee, SM and Bell, DJ and Polizzi, KM and Freemont, PS},
doi = {10.1021/acssynbio.0c00177},
journal = {ACS Synthetic Biology},
title = {Correction to EcoFlex: a multifunctional MoClo kit for E. coli synthetic biology.},
url = {http://dx.doi.org/10.1021/acssynbio.0c00177},
year = {2020}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It has been brought to our attention that the original article contains a typographical error within Figure 1B, part ii. One of the 4-bp overhangs reads “GGAC” and should instead be “GTAC”, as is consistent throughout the original manuscript and deposited AddGene sequences.
AU  - Moore,SJ
AU  - Lai,H-E
AU  - Kelwick,RJR
AU  - Chee,SM
AU  - Bell,DJ
AU  - Polizzi,KM
AU  - Freemont,PS
DO  - 10.1021/acssynbio.0c00177
PY  - 2020///
SN  - 2161-5063
TI  - Correction to EcoFlex: a multifunctional MoClo kit for E. coli synthetic biology.
T2  - ACS Synthetic Biology
UR  - http://dx.doi.org/10.1021/acssynbio.0c00177
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32301602
UR  - https://pubs.acs.org/doi/10.1021/acssynbio.0c00177
ER  -