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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Wen:2020:10.1002/bit.27333,
author = {Wen, Z and Ledesma-Amaro, R and Lu, M and Jiang, Y and Gao, S and Jin, M and Yang, S},
doi = {10.1002/bit.27333},
journal = {BIOTECHNOLOGY AND BIOENGINEERING},
pages = {2008--2022},
title = {Combined evolutionary engineering and genetic manipulation improve low pH tolerance and butanol production in a synthetic microbial <i>Clostridium</i> community},
url = {http://dx.doi.org/10.1002/bit.27333},
volume = {117},
year = {2020}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Wen,Z
AU  - Ledesma-Amaro,R
AU  - Lu,M
AU  - Jiang,Y
AU  - Gao,S
AU  - Jin,M
AU  - Yang,S
DO  - 10.1002/bit.27333
EP  - 2022
PY  - 2020///
SN  - 0006-3592
SP  - 2008
TI  - Combined evolutionary engineering and genetic manipulation improve low pH tolerance and butanol production in a synthetic microbial <i>Clostridium</i> community
T2  - BIOTECHNOLOGY AND BIOENGINEERING
UR  - http://dx.doi.org/10.1002/bit.27333
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000540022600008&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
VL  - 117
ER  -