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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Riangrungroj:2020:10.1111/1751-7915.13465,
author = {Riangrungroj, P and Polizzi, KM},
doi = {10.1111/1751-7915.13465},
journal = {Microbial Biotechnology},
pages = {311--314},
title = {BeQuIK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms.},
url = {http://dx.doi.org/10.1111/1751-7915.13465},
volume = {13},
year = {2020}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This opinion piece describes a new design for the remediation of recalcitrant biofilms. It builds on previous work to develop engineered E. coli that recognize quorum sensing signals from pathogens in a biofilm and secrete toxins in response. To solve the challenge of dilute signalling molecules, we propose to use nanobodies and enzymes displayed on the surface of the cells to localize them to the biofilm and degrade the extracellular polymeric substances, thus creating a solution with better 'seek and destroy' capabilities.
AU  - Riangrungroj,P
AU  - Polizzi,KM
DO  - 10.1111/1751-7915.13465
EP  - 314
PY  - 2020///
SN  - 1751-7915
SP  - 311
TI  - BeQuIK (Biosensor Engineered Quorum Induced Killing): designer bacteria for destroying recalcitrant biofilms.
T2  - Microbial Biotechnology
UR  - http://dx.doi.org/10.1111/1751-7915.13465
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31328393
UR  - https://sfamjournals.onlinelibrary.wiley.com/doi/full/10.1111/1751-7915.13465
UR  - http://hdl.handle.net/10044/1/72302
VL  - 13
ER  -