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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Larroude:2018:10.1016/j.biotechadv.2018.10.004,
author = {Larroude, M and Rossignol, T and Nicaud, J-M and Ledesma, Amaro R},
doi = {10.1016/j.biotechadv.2018.10.004},
journal = {Biotechnology Advances},
pages = {2150--2164},
title = {Synthetic biology tools for engineering Yarrowia lipolytica},
url = {http://dx.doi.org/10.1016/j.biotechadv.2018.10.004},
volume = {36},
year = {2018}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this review, we present recently developed synthetic biology tools that facilitate the manipulation of Y. lipolytica, including 1) DNA assembly techniques, 2) DNA parts for constructing expression cassettes, 3) genome-editing techniques, and 4) computational tools.
AU  - Larroude,M
AU  - Rossignol,T
AU  - Nicaud,J-M
AU  - Ledesma,Amaro R
DO  - 10.1016/j.biotechadv.2018.10.004
EP  - 2164
PY  - 2018///
SN  - 0734-9750
SP  - 2150
TI  - Synthetic biology tools for engineering Yarrowia lipolytica
T2  - Biotechnology Advances
UR  - http://dx.doi.org/10.1016/j.biotechadv.2018.10.004
UR  - http://hdl.handle.net/10044/1/65509
VL  - 36
ER  -