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Research

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology.

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Gamboa-Melendez:2018:10.1007/978-1-4939-8672-9_13,
author = {Gamboa-Melendez, H and Larroude, M and Park, YK and Trebul, P and Nicaud, J-M and Ledesma-Amaro, R},
doi = {10.1007/978-1-4939-8672-9_13},
journal = {Methods Mol Biol},
pages = {229--242},
title = {Synthetic Biology to Improve the Production of Lipases and Esterases (Review).},
url = {http://dx.doi.org/10.1007/978-1-4939-8672-9_13},
volume = {1835},
year = {2018}
}

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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Synthetic biology is an emergent field of research whose aim is to make biology an engineering discipline, thus permitting to design, control, and standardize biological processes. Synthetic biology is therefore expected to boost the development of biotechnological processes such as protein production and enzyme engineering, which can be significantly relevant for lipases and esterases.
AU  - Gamboa-Melendez,H
AU  - Larroude,M
AU  - Park,YK
AU  - Trebul,P
AU  - Nicaud,J-M
AU  - Ledesma-Amaro,R
DO  - 10.1007/978-1-4939-8672-9_13
EP  - 242
PY  - 2018///
SP  - 229
TI  - Synthetic Biology to Improve the Production of Lipases and Esterases (Review).
T2  - Methods Mol Biol
UR  - http://dx.doi.org/10.1007/978-1-4939-8672-9_13
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30109656
VL  - 1835
ER  -