In this section
@article{Lawlor:2020:10.1101/gad.336917.120,
author = {Lawlor, K and Marques-Torrejon, MA and Dharmalingham, G and El-Azhar, Y and Schneider, M and Pollard, S and Rodríguez, T and Rodriguez, T},
doi = {10.1101/gad.336917.120},
journal = {Genes and Development},
pages = {1599--1604},
title = {Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signalling},
url = {http://dx.doi.org/10.1101/gad.336917.120},
volume = {34},
year = {2020}
}
TY - JOUR
AB - There is increasing evidence demonstrating that adult neural stem cells (NSCs) are a cell of origin of glioblastoma. Here we analyzed the interaction between transformed and wild-type NSCs isolated from the adult mouse subventricular zone niche. We found that transformed NSCs are refractory to quiescence-inducing signals. Unexpectedly, we also demonstrated that these cells induce quiescence in surrounding wild-type NSCs in a cell–cell contact and Notch signaling-dependent manner. Our findings therefore suggest that oncogenic mutations are propagated in the stem cell niche not just through cell-intrinsic advantages, but also by outcompeting neighboring stem cells through repression of their proliferation.
AU - Lawlor,K
AU - Marques-Torrejon,MA
AU - Dharmalingham,G
AU - El-Azhar,Y
AU - Schneider,M
AU - Pollard,S
AU - Rodríguez,T
AU - Rodriguez,T
DO - 10.1101/gad.336917.120
EP - 1604
PY - 2020///
SN - 0890-9369
SP - 1599
TI - Glioblastoma stem cells induce quiescence in surrounding neural stem cells via Notch signalling
T2 - Genes and Development
UR - http://dx.doi.org/10.1101/gad.336917.120
UR - http://hdl.handle.net/10044/1/84561
VL - 34
ER -