In this section
@article{Ouyang:2020:10.1002/adfm.201908349,
author = {Ouyang, L and Armstrong, J and Chen, Q and Lin, Y and Stevens, M},
doi = {10.1002/adfm.201908349},
journal = {Advanced Functional Materials},
title = {Void-free 3D bioprinting for in-situ endothelialization and microfluidic perfusion},
url = {http://dx.doi.org/10.1002/adfm.201908349},
volume = {30},
year = {2020}
}
TY - JOUR
AB - Two major challenges of 3D bioprinting are the retention of structural fidelity and efficient endothelialization for tissue vascularization. We address both of these issues by introducinga versatile3D bioprinting strategy, in which a templating bioink is deposited layer-by-layer alongside a matrix bioink to establish void-free multimaterial structures. After crosslinking the matrix phase, the templating phase issacrificedto create a well-defined 3D network of interconnected tubular channels. This void-free 3D printing (VF-3DP) approachcircumvents the traditional concerns of structural collapse, deformation and oxygen inhibition, moreover, it can be readily used to printmaterials that are widely considered “unprintable”. By pre-loading endothelial cells into the templating bioink, the inner surface of the channels can be efficiently cellularized with a confluent endothelial layer. This in-situ endothelializationmethod can be used to produce endothelium with a far greater uniformity than can be achieved using the conventional post-seeding approach. This VF-3DP approach canalsobe extended beyond tissue fabrication and towards customized hydrogel-based microfluidics and self-supported perfusable hydrogel constructs.
AU - Ouyang,L
AU - Armstrong,J
AU - Chen,Q
AU - Lin,Y
AU - Stevens,M
DO - 10.1002/adfm.201908349
PY - 2020///
SN - 1616-301X
TI - Void-free 3D bioprinting for in-situ endothelialization and microfluidic perfusion
T2 - Advanced Functional Materials
UR - http://dx.doi.org/10.1002/adfm.201908349
UR - http://hdl.handle.net/10044/1/74627
VL - 30
ER -