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BibTex format

@article{Sun:2024:10.1084/jem.20241091,
author = {Sun, W and Gao, C and Gladkov, GT and Roseto, I and Carrere, L and Parsons, EM and Gasca-Capote, C and Frater, J and Fidler, S and Yu, XG and Lichterfeld, M and Sandström, E and Darbyshire, J and Post, F and Conlon, C and Anderson, J and Maini, M and Peto, T and Sasieni, P and Miller, V and Weller, I and Fidler, S and Frater, J and Babiker, A and Stöhr, W and Pett, S and Dorrell, L and Pace, M and Olejniczak, N and Brown, H and Robinson, N and Kopycinski, J and Yang, H and Hanke, T and Crook, A and Kaye, S and McClure, M and Erlwein, O and Lovell, A and Khan, M and Gabriel, M and Bennett, R and Sy, A and Gregory, A and Hudson, F and Russell, C and Wood, G and Box, H and Kingsley, C and Topping, K and Lever, A and Wills, M and Fun, A and Bandara, M and Kelly, D and Collins, S and Markham, A and Rauchenberger, M and Sowunmi, Y and Shidfar, S and Hague, D and Fidler, S and Pett, S and Nelson, M and Cerrone, M and Castrillo, Martinez N and Barber, T and Schoolmeesters, A and Weaver, C and },
doi = {10.1084/jem.20241091},
journal = {Journal of Experimental Medicine},
title = {Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection},
url = {http://dx.doi.org/10.1084/jem.20241091},
volume = {221},
year = {2024}
}
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TY  - JOUR
AB  - Antiretroviral treatment (ART) initiation during the early stages of HIV-1 infection is associated with a higher probability of maintaining drug-free viral control during subsequent treatment interruptions, for reasons that remain unclear. Using samples from a randomized-controlled human clinical trial evaluating therapeutic HIV-1 vaccines, we here show that early ART commencement is frequently associated with accelerated and efficient selection of genome-intact HIV-1 proviruses in repressive chromatin locations during the first year after treatment initiation. This selection process was unaffected by vaccine-induced HIV-1-specific T cell responses. Single-cell proteogenomic profiling demonstrated that cells harboring intact HIV-1 displayed a discrete phenotypic signature of immune selection by innate immune responses, characterized by a slight but significant upregulation of HLA-C, HLA-G, the IL-10 receptor, and other markers involved in innate immune regulation. Together, these results suggest an accelerated immune selection of viral reservoir cells during early-treated HIV-1 infection that seems at least partially driven by innate immune responses.
AU  - Sun,W
AU  - Gao,C
AU  - Gladkov,GT
AU  - Roseto,I
AU  - Carrere,L
AU  - Parsons,EM
AU  - Gasca-Capote,C
AU  - Frater,J
AU  - Fidler,S
AU  - Yu,XG
AU  - Lichterfeld,M
AU  - Sandström,E
AU  - Darbyshire,J
AU  - Post,F
AU  - Conlon,C
AU  - Anderson,J
AU  - Maini,M
AU  - Peto,T
AU  - Sasieni,P
AU  - Miller,V
AU  - Weller,I
AU  - Fidler,S
AU  - Frater,J
AU  - Babiker,A
AU  - Stöhr,W
AU  - Pett,S
AU  - Dorrell,L
AU  - Pace,M
AU  - Olejniczak,N
AU  - Brown,H
AU  - Robinson,N
AU  - Kopycinski,J
AU  - Yang,H
AU  - Hanke,T
AU  - Crook,A
AU  - Kaye,S
AU  - McClure,M
AU  - Erlwein,O
AU  - Lovell,A
AU  - Khan,M
AU  - Gabriel,M
AU  - Bennett,R
AU  - Sy,A
AU  - Gregory,A
AU  - Hudson,F
AU  - Russell,C
AU  - Wood,G
AU  - Box,H
AU  - Kingsley,C
AU  - Topping,K
AU  - Lever,A
AU  - Wills,M
AU  - Fun,A
AU  - Bandara,M
AU  - Kelly,D
AU  - Collins,S
AU  - Markham,A
AU  - Rauchenberger,M
AU  - Sowunmi,Y
AU  - Shidfar,S
AU  - Hague,D
AU  - Fidler,S
AU  - Pett,S
AU  - Nelson,M
AU  - Cerrone,M
AU  - Castrillo,Martinez N
AU  - Barber,T
AU  - Schoolmeesters,A
AU  - Weaver,C
AU  - Thunder,O
AU  - Rowlands,J
AU  - Higgs,C
AU  - Fedele,S
AU  - Bracchi,M
AU  - Thomas,L
AU  - Bourke,P
AU  - Nwokolo,N
AU  - Lawrenson,G
AU  - Fiorino,M
AU  - Lukha,H
AU  - Kinloch,S
AU  - Johnson,M
AU  - Nightingale,A
AU  - Ngwu,N
AU  - Byrne,P
AU  - Cuthbertson,Z
AU  - Jones,M
AU  - Fernandez,T
AU  - Clarke,A
AU  - Fisher,M
AU  - Gleig,R
AU  - Trevitt,V
AU  - Fitzpatrick,C
AU  - Adams,T
AU  - Finnerty,F
AU  - Thornhill,J
AU  - Lewis,H
AU  - Kuldanek,K
AU  - Fox,J
AU  - Lwanga,J
AU  - Uzu,H
AU  - Lee,M
AU  - Merle,S
AU  - ORourke,P
AU  - Jendrulek,I
AU  - ZarkoFlynn,T
AU  - Taylor,M
AU  - Tiraboschi,JM
AU  - Murray,T
DO  - 10.1084/jem.20241091
PY  - 2024///
SN  - 0022-1007
TI  - Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection
T2  - Journal of Experimental Medicine
UR  - http://dx.doi.org/10.1084/jem.20241091
UR  - http://hdl.handle.net/10044/1/115510
VL  - 221
ER  -
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