In this section
@article{Cesarec:2020:10.2174/1874471013666200907115026,
author = {Cesarec, S and Robson, JA and Carroll, LS and Aboagye, EO and Spivey, AC},
doi = {10.2174/1874471013666200907115026},
journal = {Current Radiopharmaceuticals},
title = {Direct incorporation of [18F] into Aliphatic Systems: a promising Mn-catalysed labelling technique for PET imaging},
url = {http://dx.doi.org/10.2174/1874471013666200907115026},
volume = {13},
year = {2020}
}
TY - JOUR
AB - BACKGROUND: One of the challenges in positron emission tomography (PET) is labellingcomplex aliphatic molecules. OBJECTIVE: This study aimed to develop a method of metal-catalysed radiofluorination that is site-selectiveand works in moderate to good yields under facile conditions. METHODS: Herein, we report on the optimisation of an aliphatic C-H to C-18F bond transformationcatalysed by a Mn(porphyrin) complex. RESULTS: The successful oxidation of 11 aliphatic molecules, including progesterone, is reported.Radiochemical Incorporations (RCIs) up to 69% were achieved within 60 min without the need forpre-activation or special equipment. CONCLUSION: The method features mild conditions (60 °C) and promises to constitute a valuable approachto labelling of biomolecules and drug substances.
AU - Cesarec,S
AU - Robson,JA
AU - Carroll,LS
AU - Aboagye,EO
AU - Spivey,AC
DO - 10.2174/1874471013666200907115026
PY - 2020///
SN - 1874-4710
TI - Direct incorporation of [18F] into Aliphatic Systems: a promising Mn-catalysed labelling technique for PET imaging
T2 - Current Radiopharmaceuticals
UR - http://dx.doi.org/10.2174/1874471013666200907115026
UR - https://www.ncbi.nlm.nih.gov/pubmed/32895047
UR - https://www.eurekaselect.com/185657/article
UR - http://hdl.handle.net/10044/1/85982
VL - 13
ER -
Email: a.c.spivey@imperial.ac.uk
Skype: alan.spivey
Tel & Fax: +44 (0)20 75945841
Further links: