In this section
@article{Nielsen:2019:10.26434/chemrxiv.8052623.v1,
author = {Nielsen, C and White, A and Sale, D and Bures, J and Spivey, A},
doi = {10.26434/chemrxiv.8052623.v1},
journal = {ChemRxiv},
title = {Hydroarylation of Alkenes by protonation/Friedel-Crafts Trapping – HFIP-Mediated Access to Per-Aryl Quaternary Stereocentres},
url = {http://dx.doi.org/10.26434/chemrxiv.8052623.v1},
year = {2019}
}
TY - JOUR
AB - <div> <p>Upon treatment with a combination of HFIP and a strong Brønsted acid, alkenes behave as Brønsted bases and protonate to give carbocations which can be trapped by electron rich arenes. The reaction constitutes a Friedel-Crafts (FC) hydroarylation which proceeds with Markovnikov selectivity and is orthogonal to traditional metal catalyzed processes. The products contain polyarylated quaternary carbon atoms which are difficult to obtain <i>via</i> alternative methods. Intermolecular transfer hydrogenation and hydrothiolation are also demonstrated. </p> </div>
AU - Nielsen,C
AU - White,A
AU - Sale,D
AU - Bures,J
AU - Spivey,A
DO - 10.26434/chemrxiv.8052623.v1
PY - 2019///
TI - Hydroarylation of Alkenes by protonation/Friedel-Crafts Trapping – HFIP-Mediated Access to Per-Aryl Quaternary Stereocentres
T2 - ChemRxiv
UR - http://dx.doi.org/10.26434/chemrxiv.8052623.v1
ER -
Email: a.c.spivey@imperial.ac.uk
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