In this section
@article{Adamo:2017:10.1039/c7lc00179g,
author = {Adamo, M and Poulos, AS and Miller, RM and Lopez, CG and Martel, A and Porcar, L and Cabral, JT},
doi = {10.1039/c7lc00179g},
journal = {Lab on a Chip},
pages = {1559--1569},
title = {Rapid contrast matching by microfluidic SANS},
url = {http://dx.doi.org/10.1039/c7lc00179g},
volume = {17},
year = {2017}
}
TY - JOUR
AB - We report a microfluidic approach to perform small angle neutron scattering (SANS) measurements of contrast variation and matching, extensively employed in soft and biological matter research. We integrate a low scattering background microfluidic mixer and serpentine channel in a SANS beamline to yield a single phase, continuous flow, reconfigurable liquid cell. By contrast with conventional, sequential measurements of discrete (typically 4–6) solutions of varying isotopic solvent composition, our approach continually varies solution composition during SANS acquisition. We experimentally and computationally determine the effects of flow dispersion and neutron beam overillumination of microchannels in terms of the composition resolution and precision. The approach is demonstrated with model systems: H2O/D2O mixtures, a surfactant (sodium dodecyl sulfate, SDS), a triblock copolymer (pluronic F127), and silica nanoparticles (Ludox) in isotopic aqueous mixtures. The system is able to zoom into a composition window to refine contrast matching conditions, and robustly resolve solute structure and form factors by simultaneous fitting of scattering data with continuously varying contrast. We conclude by benchmarking our microflow-SANS with the discrete approach, in terms of volume required, composition resolution and (preparation and measurement) time required, proposing a leap forward in equilibrium, liquid solution phase mapping and contrast variation by SANS.
AU - Adamo,M
AU - Poulos,AS
AU - Miller,RM
AU - Lopez,CG
AU - Martel,A
AU - Porcar,L
AU - Cabral,JT
DO - 10.1039/c7lc00179g
EP - 1569
PY - 2017///
SN - 1473-0189
SP - 1559
TI - Rapid contrast matching by microfluidic SANS
T2 - Lab on a Chip
UR - http://dx.doi.org/10.1039/c7lc00179g
UR - http://hdl.handle.net/10044/1/52111
VL - 17
ER -