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• Conference paper
  Amin HD, Brady MA, St-Pierre J-P, Stevens MM, Overby DR, Ethier CRet al., 2013,

  STIMULATION OF CHONDROGENIC DIFFERENTIATION OF ADULT HUMAN PRECURSOR CELLS USING STATIC MAGNETIC FIELD AS A PHYSICAL CUE

  , World Congress of the Osteoarthritis-Research-Society-International (OARSI), Publisher: ELSEVIER SCI LTD, Pages: S118-S118, ISSN: 1063-4584
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  • Citations: 1
• Journal article
  Francis AW, Kagemann L, Wollstein G, Ishikawa H, Folz S, Overby DR, Sigal IA, Wang B, Schuman JSet al., 2012,

  Morphometric Analysis of Aqueous Humor Outflow Structures with Spectral-Domain Optical Coherence Tomography

  , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 53, Pages: 5198-5207, ISSN: 0146-0404
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  • Citations: 42
• Journal article
  Boussommier-Calleja A, Bertrand J, Woodward DF, Ethier CR, Stamer WD, Overby DRet al., 2012,

  Pharmacologic Manipulation of Conventional Outflow Facility in Ex Vivo Mouse Eyes

  , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 53, Pages: 5838-5845, ISSN: 0146-0404
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  • Citations: 66
• Journal article
  Warboys CM, Overby DR, Weinberg PD, 2012,

  Dendritic Cells Lower the Permeability of Endothelial Monolayers

  , CELLULAR AND MOLECULAR BIOENGINEERING, Vol: 5, Pages: 184-193, ISSN: 1865-5025
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  • Citations: 6
• Journal article
  Sherwood JM, Dusting J, Kaliviotis E, Balabani Set al., 2012,

  The effect of red blood cell aggregation on velocity and cell-depleted layer characteristics of blood in a bifurcating microchannel

  , Biomicrofluidics, Vol: 6, ISSN: 1932-1058

  Red blood cell (RBC) aggregation is a multifaceted phenomenon, and whether it is generally beneficial or deleterious remains unclear. In order to better understand its effect on microvascular blood flow, the phenomenon must be studied in complex geometries, as it is strongly dependent on time, flow, and geometry. The cell-depleted layer (CDL) which forms at the walls of microvessels has been observed to be enhanced by aggregation; however, details of the characteristics of the CDL in complex regions, such as bifurcations, require further investigation. In the present study, a microchannel with a T-junction was used to analyze the influence of aggregation on the flow field and the CDL. Micro-PIV using RBCs as tracers provided high resolution cell velocity data. CDL characteristics were measured from the same data using a newly developed technique based on motion detection. Skewed and sharpened velocity profiles in the daughter branches were observed, contrary to the behavior of a continuous Newtonian fluid. RBC aggregation was observed to increase the skewness, but decrease the sharpening, of the velocity profiles in the daughter branches. The CDL width was found to be significantly greater, with a wider distribution, in the presence of aggregation and the mean width increased proportionally with the reciprocal of the fraction of flow entering the daughter branch. Aggregation also significantly increased the roughness of the interface between the CDL and the RBC core. The present results provide further insight into how RBC aggregation may affect the flow in complex geometries, which is of importance in both understanding its functions invivo, and utilizing it as a tool in microfluidic devices.

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• Conference paper
  Pedrigi RM, Gupta R, Braakman ST, Stamer WD, Ethier CR, Overby DRet al., 2012,

  PORE FORMATION IN SCHLEMM'S CANAL ENDOTHELIAL CELLS IS MECHANO-SENSITIVE AND IMPAIRED IN GLAUCOMA

  , ASME Summer Bioengineering Conference (SBC), Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 1183-1184
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• Journal article
  Stamer WD, Lei Y, Boussommier-Calleja A, Overby DR, Ethier CRet al., 2011,

  eNOS, a Pressure-Dependent Regulator of Intraocular Pressure

  , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 52, Pages: 9438-9444, ISSN: 0146-0404
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  • Citations: 125
• Journal article
  Lei Y, Rajabi S, Pedrigi RM, Overby DR, Read AT, Ethier CRet al., 2011,

  In Vitro Models for Glaucoma Research: Effects of Hydrostatic Pressure

  , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 52, Pages: 6329-6339, ISSN: 0146-0404
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  • Citations: 24
• Journal article
  Lei Y, Overby DR, Boussommier-Calleja A, Stamer WD, Ethier CRet al., 2011,

  Outflow Physiology of the Mouse Eye: Pressure Dependence and Washout

  , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 52, Pages: 1865-1871, ISSN: 0146-0404
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  • Citations: 80
• Journal article
  VanderWyst SS, Perkumas KM, Read AT, Overby DR, Stamer WDet al., 2011,

  Structural basement membrane components and corresponding integrins in Schlemm's canal endothelia

  , MOLECULAR VISION, Vol: 17, Pages: 199-209, ISSN: 1090-0535
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  • Citations: 18
• Journal article
  Pedrigi RM, Simon D, Reed A, Stamer WD, Overby DRet al., 2011,

  A model of giant vacuole dynamics in human Schlemm's canal endothelial cells

  , EXPERIMENTAL EYE RESEARCH, Vol: 92, Pages: 57-66, ISSN: 0014-4835
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  • Citations: 35
• Book chapter
  Overby DR, 2011,

  The mechanobiology of aqueous humor transport across Schlemm’s canal endothelium.

  , Mechanobiology Handbook, Editors: Nigatomi, Publisher: CRC Press, Taylor & Francis Group, LLC
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• Journal article
  Lei Y, Overby DR, Read AT, Stamer WD, Ethier CRet al., 2010,

  A New Method for Selection of Angular Aqueous Plexus Cells from Porcine Eyes: A Model for Schlemm's Canal Endothelium

  , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 51, Pages: 5744-5750, ISSN: 0146-0404
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  • Citations: 24
• Conference paper
  Warboys CM, Overby DR, Weinberg PD, 2010,

  Dendritic cells lower permeability of endothelial cell monolayers

  , Publisher: ELSEVIER IRELAND LTD, Pages: E17-E17, ISSN: 0021-9150
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• Journal article
  Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DEet al., 2010,

  Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

  , INTEGRATIVE BIOLOGY, Vol: 2, Pages: 435-442, ISSN: 1757-9694
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  • Citations: 181

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