BibTex format
@article{Aleksandrova:2014:10.1186/s12916-014-0168-4,
author = {Aleksandrova, K and Pischon, T and Jenab, M and Bueno-de-Mesquita, HB and Fedirko, V and Norat, T and Romaguera, D and Knueppel, S and Boutron-Ruault, M-C and Dossus, L and Dartois, L and Kaaks, R and Li, K and Tjonneland, A and Overvad, K and Quiros, JR and Buckland, G and Sanchez, MJ and Dorronsoro, M and Chirlaque, M-D and Barricarte, A and Khaw, K-T and Wareham, NJ and Bradbury, KE and Trichopoulou, A and Lagiou, P and Trichopoulos, D and Palli, D and Krogh, V and Tumino, R and Naccarati, A and Panico, S and Siersema, PD and Peeters, PHM and Ljuslinder, I and Johansson, I and Ericson, U and Ohlsson, B and Weiderpass, E and Skeie, G and Borch, KB and Rinaldi, S and Romieu, I and Kong, J and Gunter, MJ and Ward, HA and Riboli, E and Boeing, H},
doi = {10.1186/s12916-014-0168-4},
journal = {BMC Medicine},
title = {Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study},
url = {http://dx.doi.org/10.1186/s12916-014-0168-4},
volume = {12},
year = {2014}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Background: Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors areindividually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of thisstudy was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors –healthy weight, physical activity, non-smoking, limited alcohol consumption and a healthy diet, and to explore theassociation of this index with CRC incidence using data collected within the European Prospective Investigation intoCancer and Nutrition (EPIC) cohort.Methods: In the EPIC cohort, a total of 347,237 men and women, 25- to 70-years old, provided dietary and lifestyleinformation at study baseline (1992 to 2000). Over a median follow-up time of 12 years, 3,759 incident CRC caseswere identified. The association between a HLI and CRC risk was evaluated using Cox proportional hazardsregression models and population attributable risks (PARs) have been calculated.Results: After accounting for study centre, age, sex and education, compared with 0 or 1 healthy lifestyle factors,the hazard ratio (HR) for CRC was 0.87 (95% confidence interval (CI): 0.44 to 0.77) for two factors, 0.79 (95% CI: 0.70to 0.89) for three factors, 0.66 (95% CI: 0.58 to 0.75) for four factors and 0.63 (95% CI: 0.54 to 0.74) for five factors;P-trend <0.0001. The associations were present for both colon and rectal cancers, HRs, 0.61 (95% CI: 0.50 to 0.74; Pfor trend <0.0001) for colon cancer and 0.68 (95% CI: 0.53 to 0.88; P-trend <0.0001) for rectal cancer, respectively(P-difference by cancer sub-site = 0.10). Overall, 16% of the new CRC cases (22% in men and 11% in women) wereattributable to not adhering to a combination of all five healthy lifestyle behaviours included in the index.Conclusions: Combined lifestyle factors are associated with a lower incidence of CRC in European populationscharacterized by western lifestyles. Prevention str
AU - Aleksandrova,K
AU - Pischon,T
AU - Jenab,M
AU - Bueno-de-Mesquita,HB
AU - Fedirko,V
AU - Norat,T
AU - Romaguera,D
AU - Knueppel,S
AU - Boutron-Ruault,M-C
AU - Dossus,L
AU - Dartois,L
AU - Kaaks,R
AU - Li,K
AU - Tjonneland,A
AU - Overvad,K
AU - Quiros,JR
AU - Buckland,G
AU - Sanchez,MJ
AU - Dorronsoro,M
AU - Chirlaque,M-D
AU - Barricarte,A
AU - Khaw,K-T
AU - Wareham,NJ
AU - Bradbury,KE
AU - Trichopoulou,A
AU - Lagiou,P
AU - Trichopoulos,D
AU - Palli,D
AU - Krogh,V
AU - Tumino,R
AU - Naccarati,A
AU - Panico,S
AU - Siersema,PD
AU - Peeters,PHM
AU - Ljuslinder,I
AU - Johansson,I
AU - Ericson,U
AU - Ohlsson,B
AU - Weiderpass,E
AU - Skeie,G
AU - Borch,KB
AU - Rinaldi,S
AU - Romieu,I
AU - Kong,J
AU - Gunter,MJ
AU - Ward,HA
AU - Riboli,E
AU - Boeing,H
DO - 10.1186/s12916-014-0168-4
PY - 2014///
SN - 1741-7015
TI - Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study
T2 - BMC Medicine
UR - http://dx.doi.org/10.1186/s12916-014-0168-4
UR - http://hdl.handle.net/10044/1/28179
VL - 12
ER -
