In this section
@article{Bordeu:2020:10.1103/PhysRevX.10.041022,
author = {Bordeu, Weldt I and Garcin, C and Habib, SJ and Pruessner, G},
doi = {10.1103/PhysRevX.10.041022},
journal = {Physical Review X},
pages = {041022 1--041022 18},
title = {Effective potential description of the interaction between single stem cells and localized ligands},
url = {http://dx.doi.org/10.1103/PhysRevX.10.041022},
volume = {10},
year = {2020}
}
TY - JOUR
AB - Cell signalling is essential for cell fate determination and tissue patterning. As signalling ligandsare presented to the receiving cell, they are recruited and recognised by the cell membrane as to elicita biological response and to pattern multicellular tissues. Cells can accumulate and transport theseligands, which results in an emergent organisation of the ligands' spatial distribution. To study thisorganisation, we make use of a simpli ed experimental setup, in which single mouse embryonic stemcells (mESCs) can interact with immobilized ligands. We introduce a two species age-dependentcorrelation function that allows the description and quanti cation of the spatio-temporal dynamicsof single cell-ligand interactions. Through the analysis of mESC data and numerical simulations weshow that cells act as e ective force- eld generators, perturbing and organising their environment.This organisation, captured in the form of an ageing e ective potential, is an emergent property ofthe population of single cells interacting with randomly distributed localized ligands.
AU - Bordeu,Weldt I
AU - Garcin,C
AU - Habib,SJ
AU - Pruessner,G
DO - 10.1103/PhysRevX.10.041022
EP - 1
PY - 2020///
SN - 2160-3308
SP - 041022
TI - Effective potential description of the interaction between single stem cells and localized ligands
T2 - Physical Review X
UR - http://dx.doi.org/10.1103/PhysRevX.10.041022
UR - https://journals.aps.org/prx/abstract/10.1103/PhysRevX.10.041022
UR - http://hdl.handle.net/10044/1/83428
VL - 10
ER -