BibTex format
@article{Youngstein:2017:10.1016/j.jcmg.2016.09.027,
author = {Youngstein, T and Tombetti, E and Mukherjee, J and Barwick, TD and Al-Nahhas, A and Humphreys, E and Nash, J and Andrews, J and Incerti, E and Tombolini, E and Salerno, A and Sartorelli, S and Ramirez, GA and Papa, M and Sabbadini, MG and Gianolli, L and De, Cobelli F and Fallanca, F and Baldissera, E and Manfredi, AA and Picchio, M and Mason, JC},
doi = {10.1016/j.jcmg.2016.09.027},
journal = {JACC: Cardiovascular Imaging},
pages = {1042--1052},
title = {FDG uptake by prosthetic arterial grafts in large vessel vasculitis Is not specific for active disease},
url = {http://dx.doi.org/10.1016/j.jcmg.2016.09.027},
volume = {10},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - OBJECTIVES: This study investigated the incidence and clinical significance of arterial graft-associated uptake of fluorodeoxyglucose in large-vessel vasculitis (LVV). BACKGROUND: The role of (18)F-labeled fluorodeoxyglucose-positron emission tomography/computed tomography ([(18)F]FDG-PET/CT) in the management of LVV remains to be defined. Although [(18)F]FDG uptake at arterial graft sites raises concerns regarding active arteritis or infection, its clinical significance in LVV has never been formally studied. METHODS: An observational prospective study sought to identify patients with Takayasu arteritis (TA) undergoing [(18)F]FDG-PET/CT more than 6 months after graft surgery from a large cohort of patients from 2 tertiary referral centers. [(18)F]FDG uptake by the graft and native arteries was scored on a scale of 0 to 3 relative to hepatic uptake, and periprosthetic maximum standardized uptake value (SUVmax) was calculated. Periprosthetic [(18)F]FDG uptake in active disease was compared with that in inactive disease, and arterial progression was assessed by prospective magnetic resonance angiography (MRA). RESULTS: Twenty-six subjects with TA were enrolled. All were afebrile with negative blood culture. Periprosthetic uptake was significant in 23 of 26 patients, and the mean SUVmax was 4.21 ± 1.46. Median periprosthetic [(18)F]FDG uptake score (3; interquartile range [IQR]: 3 to 3) was higher than in native aorta (1; IQR: 0 to 1; p < 0.001). Graft-specific [(18)F]FDG uptake was unrelated to disease activity. Despite the high frequency of graft-associated [(18)F]FDG uptake, sequential MRAs did not reveal arterial progression in 25 of 26 patients; the 1 remaining case showed minor progression limited to native arteries. Nine patients underwent repeated PET/CT scanning without showing changes in graft-specific uptake, despite increased treatment. CONCLUSIONS: Significant [(18)F]FDG uptake that is confined to arterial graft sites in patients w
AU - Youngstein,T
AU - Tombetti,E
AU - Mukherjee,J
AU - Barwick,TD
AU - Al-Nahhas,A
AU - Humphreys,E
AU - Nash,J
AU - Andrews,J
AU - Incerti,E
AU - Tombolini,E
AU - Salerno,A
AU - Sartorelli,S
AU - Ramirez,GA
AU - Papa,M
AU - Sabbadini,MG
AU - Gianolli,L
AU - De,Cobelli F
AU - Fallanca,F
AU - Baldissera,E
AU - Manfredi,AA
AU - Picchio,M
AU - Mason,JC
DO - 10.1016/j.jcmg.2016.09.027
EP - 1052
PY - 2017///
SN - 1936-878X
SP - 1042
TI - FDG uptake by prosthetic arterial grafts in large vessel vasculitis Is not specific for active disease
T2 - JACC: Cardiovascular Imaging
UR - http://dx.doi.org/10.1016/j.jcmg.2016.09.027
UR - http://hdl.handle.net/10044/1/49968
VL - 10
ER -