BibTex format
@article{Khan:2016:10.1038/srep38104,
author = {Khan, E and Ambrose, N and Ahnstrom, J and Kiprianos, A and Stanford, M and Eleftheriou, D and Brogan, P and Mason, J and Johns, M and Laffan, M and Haskard, D},
doi = {10.1038/srep38104},
journal = {Clinical and Experimental Rheumatology},
title = {A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet’s Syndrome},
url = {http://dx.doi.org/10.1038/srep38104},
volume = {6},
year = {2016}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Thrombosis is common in Behçet’s Syndrome (BS), and there is a need for better biomarkers for risk assessment. As microparticles expressing Tissue Factor (TF) can contribute to thrombosis in preclinical models, we investigated whether plasma microparticles expressing Tissue Factor (TF) are increased in BS. We compared blood plasma from 72 healthy controls with that from 88 BS patients (21 with a history of thrombosis (Th+) and 67 without (Th−). Using flow cytometry, we found that the total plasma MP numbers were increased in BS compared to HC, as were MPs expressing TF and Tissue Factor Pathway Inhibitor (TFPI) (all p < 0.0001). Amongst BS patients, the Th+ group had increased total and TF positive MP numbers (both p ≤ 0.0002) compared to the Th- group, but had a lower proportion of TFPI positive MPs (p < 0.05). Consequently, the ratio of TFPI positive to TF positive MP counts (TFPI/TF) was significantly lower in Th+ versus Th− BS patients (p = 0.0002), and no patient with a TFPI/TF MP ratio >0.7 had a history of clinical thrombosis. We conclude that TF-expressing MP are increased in BS and that an imbalance between microparticulate TF and TFPI may predispose to thrombosis.
AU - Khan,E
AU - Ambrose,N
AU - Ahnstrom,J
AU - Kiprianos,A
AU - Stanford,M
AU - Eleftheriou,D
AU - Brogan,P
AU - Mason,J
AU - Johns,M
AU - Laffan,M
AU - Haskard,D
DO - 10.1038/srep38104
PY - 2016///
SN - 1593-098X
TI - A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behçet’s Syndrome
T2 - Clinical and Experimental Rheumatology
UR - http://dx.doi.org/10.1038/srep38104
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000388065900033&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/42368
VL - 6
ER -