Citation

BibTex format

@article{Thwaites:2017:infdis/jix150,
author = {Thwaites, RS and Ito, K and Chingono, JMS and Coates, M and Jarvis, HC and Tunstall, T and Anderson-Dring, L and Cass, L and Rapeport, G and Openshaw, PJ and Nadel, S and Hansel, TT},
doi = {infdis/jix150},
journal = {The Journal of Infectious Diseases},
pages = {1240--1244},
title = {Nasosorption is a minimally invasive diagnostic procedure for measurement of viral load and markers of mucosal inflammation in RSV bronchiolitis},
url = {http://dx.doi.org/10.1093/infdis/jix150},
volume = {215},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background.Existing respiratory mucosal sampling methods are flawed, particularly in a pediatric bronchiolitis setting.Methods.Twenty-four infants with bronchiolitis were recruited: 12 were respiratory syncytial virus (RSV)–positive, 12 were RSV-negative. Infants were sampled by nasosorption and nasopharyngeal aspiration (NPA).Results.Nasosorption was well tolerated and identified all RSV+ samples. RSV load measured by nasosorption (but not NPA) correlated with length of hospital stay (P = .04) and requirement for mechanical ventilation (P = .03). Nasosorption (but not NPA) levels of interferon γ, interleukin 1β, CCL5/RANTES, and interleukin 10 (IL-10) were elevated in RSV+ bronchiolitis (all P < .05), furthermore CCL5 and IL-10 correlated with RSV load (P < .05).Conclusions.Nasosorption allowed measurement of RSV load and the mucosal inflammatory response in infants.
AU  - Thwaites,RS
AU  - Ito,K
AU  - Chingono,JMS
AU  - Coates,M
AU  - Jarvis,HC
AU  - Tunstall,T
AU  - Anderson-Dring,L
AU  - Cass,L
AU  - Rapeport,G
AU  - Openshaw,PJ
AU  - Nadel,S
AU  - Hansel,TT
DO  - infdis/jix150
EP  - 1244
PY  - 2017///
SN  - 1537-6613
SP  - 1240
TI  - Nasosorption is a minimally invasive diagnostic procedure for measurement of viral load and markers of mucosal inflammation in RSV bronchiolitis
T2  - The Journal of Infectious Diseases
UR  - http://dx.doi.org/10.1093/infdis/jix150
UR  - http://hdl.handle.net/10044/1/45757
VL  - 215
ER  -
Download
Read the HIC-Vac blog
  • News
  • Interview

An interview with Professor Openshaw

Professor Peter Openshaw is interviewed by the Infectious Diseases Hub on influenza and immunopathogenesis