In this section
@article{Goritzka:2014:10.1128/JVI.00333-14,
author = {Goritzka, M and Durant, LR and Pereira, C and Salek-Ardakani, S and Openshaw, PJM and Johansson, C},
doi = {10.1128/JVI.00333-14},
journal = {Journal of Virology},
pages = {6128--6136},
title = {Alpha/Beta Interferon Receptor Signaling Amplifies Early Proinflammatory Cytokine Production in the Lung during Respiratory Syncytial Virus Infection},
url = {http://dx.doi.org/10.1128/JVI.00333-14},
volume = {88},
year = {2014}
}
TY - JOUR
AB - Type I interferons (IFNs) are produced early upon virus infection and signal through the alpha/beta interferon (IFN-α/β) receptor (IFNAR) to induce genes that encode proteins important for limiting viral replication and directing immune responses. To investigate the extent to which type I IFNs play a role in the local regulation of inflammation in the airways, we examined their importance in early lung responses to infection with respiratory syncytial virus (RSV). IFNAR1-deficient (IFNAR1−/−) mice displayed increased lung viral load and weight loss during RSV infection. As expected, expression of IFN-inducible genes was markedly reduced in the lungs of IFNAR1−/− mice. Surprisingly, we found that the levels of proinflammatory cytokines and chemokines in the lungs of RSV-infected mice were also greatly reduced in the absence of IFNAR signaling. Furthermore, low levels of proinflammatory cytokines were also detected in the lungs of IFNAR1−/− mice challenged with noninfectious innate immune stimuli such as selected Toll-like receptor (TLR) agonists. Finally, recombinant IFN-α was sufficient to potentiate the production of inflammatory mediators in the lungs of wild-type mice challenged with innate immune stimuli. Thus, in addition to its well-known role in antiviral resistance, type I IFN receptor signaling acts as a central driver of early proinflammatory responses in the lung. Inhibiting the effects of type I IFNs may therefore be useful in dampening inflammation in lung diseases characterized by enhanced inflammatory cytokine production.
AU - Goritzka,M
AU - Durant,LR
AU - Pereira,C
AU - Salek-Ardakani,S
AU - Openshaw,PJM
AU - Johansson,C
DO - 10.1128/JVI.00333-14
EP - 6136
PY - 2014///
SN - 0022-538X
SP - 6128
TI - Alpha/Beta Interferon Receptor Signaling Amplifies Early Proinflammatory Cytokine Production in the Lung during Respiratory Syncytial Virus Infection
T2 - Journal of Virology
UR - http://dx.doi.org/10.1128/JVI.00333-14
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000335970300021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://jvi.asm.org/content/88/11/6128/
UR - http://hdl.handle.net/10044/1/19051
VL - 88
ER -
