BibTex format
@article{Patel:2019:10.1126/sciimmunol.aax7006,
author = {Patel, DF and Peiro, T and Bruno, N and Vuononvirta, J and Akthar, S and Puttur, F and Pyle, CJ and Suveizdyte, K and Walker, SA and Singanayagam, A and Carlin, LM and Gregory, LG and Lloyd, CM and Snelgrove, R},
doi = {10.1126/sciimmunol.aax7006},
journal = {Science Immunology},
pages = {1--18},
title = {Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation},
url = {http://dx.doi.org/10.1126/sciimmunol.aax7006},
volume = {4},
year = {2019}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Neutrophil mobilization, recruitmentand clearancemust be tightly regulated asover-exuberant neutrophilic inflammation isimplicated in the pathology of chronic diseases, including asthma. Efforts to target neutrophilstherapeutically have failed to consider theirpleiotropic functions and theimplications of disrupting fundamental regulatory pathways that govern their turnover duringhomeostasisand inflammation.Using thehouse dust mite(HDM)model of allergic airways disease, we demonstrate that neutrophil depletion unexpectedly resulted in exacerbated TH2 inflammation, epithelial remodelling and airway resistance. Mechanistically, this was attributable to astriking increase insystemic G-CSF concentrations, which are ordinarily negatively regulated in the periphery by transmigrated lung neutrophils. Intriguingly, we found that increasedG-CSF augmented allergic sensitization in HDM exposed animals bydirectly acting on airway ILC2s toelicitcytokine production.Moreover, increased systemic G-CSF promoted expansion of bone marrow monocyte progenitor populations, which resulted in enhanced antigen presentation by an augmented peripheral monocyte-derived dendritic cell pool.By modelling the effects of neutrophil depletion, our studies have therefore uncovered previously unappreciated roles for G-CSF in modulating ILC2 function and antigen presentation. More broadly,they highlight an unexpected regulatory role for neutrophils in limiting TH2 allergic airway inflammation.
AU - Patel,DF
AU - Peiro,T
AU - Bruno,N
AU - Vuononvirta,J
AU - Akthar,S
AU - Puttur,F
AU - Pyle,CJ
AU - Suveizdyte,K
AU - Walker,SA
AU - Singanayagam,A
AU - Carlin,LM
AU - Gregory,LG
AU - Lloyd,CM
AU - Snelgrove,R
DO - 10.1126/sciimmunol.aax7006
EP - 18
PY - 2019///
SN - 2470-9468
SP - 1
TI - Neutrophils restrain allergic airway inflammation by limiting ILC2 function and monocyte-dendritic cell antigen presentation
T2 - Science Immunology
UR - http://dx.doi.org/10.1126/sciimmunol.aax7006
UR - http://hdl.handle.net/10044/1/74249
VL - 4
ER -
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