In this section
@article{Dal:2017:10.1183/13993003.00711-2017,
author = {Dal, Negro RW and Wedzicha, JA and Iversen, M and Fontana, G and Page, C and Cicero, AF and Pozzi, E and Calverley, PMA},
doi = {10.1183/13993003.00711-2017},
journal = {European Respiratory Journal},
title = {Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study},
url = {http://dx.doi.org/10.1183/13993003.00711-2017},
volume = {50},
year = {2017}
}
TY - JOUR
AB - Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) exacerbations and antioxidants can decrease exacerbation rates, although we lack data about the effect of such drugs on exacerbation duration.The RESTORE (Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD) study was a prospective randomised, double-blind, placebo-controlled study, enrolling patients aged 40–80years with Global Initiative for Chronic Obstructive Lung Disease stage II/III. Patients received erdosteine 300mg twice daily or placebo added to usual COPD therapy for 12months. The primary outcome was the number of acute exacerbations during the study.In the pre-specified intention-to-treat population of 445 patients (74% male; mean age 64.8years, forced expiratory volume in 1s 51.8% predicted) erdosteine reduced the exacerbation rate by 19.4% (0.91 versus. 1.13 exacerbations·patient−1·year−1 for erdosteine and placebo, respectively; p=0.01), due to an effect on mild events; the reduction in the rate of mild exacerbations was 57.1% (0.23 versus 0.54 exacerbations·patient−1·year−1 for erdosteine and placebo, respectively; p=0.002). No significant difference was observed in the rate of moderate and severe exacerbations (0.68 versus 0.59 exacerbations·patient−1·year−1 for erdosteine and placebo, respectively; p=0.054) despite a trend in favour of the comparison group. Erdosteine decreased the exacerbation duration irrespective of event severity by 24.6% (9.55 versus 12.63days for erdosteine and placebo, respectively; p=0.023). Erdosteine significantly improved subject and physician subjective severity scores (p=0.022 and p=0.048, respectively), and reduced the use of reliever medication (p<0.001), but did not affect the St George's Respiratory Questionnaire score or the time to first exacerbation.In patients with COPD, erdosteine can reduce both the rate and duration
AU - Dal,Negro RW
AU - Wedzicha,JA
AU - Iversen,M
AU - Fontana,G
AU - Page,C
AU - Cicero,AF
AU - Pozzi,E
AU - Calverley,PMA
DO - 10.1183/13993003.00711-2017
PY - 2017///
SN - 0903-1936
TI - Effect of erdosteine on the rate and duration of COPD exacerbations: the RESTORE study
T2 - European Respiratory Journal
UR - http://dx.doi.org/10.1183/13993003.00711-2017
UR - http://hdl.handle.net/10044/1/54994
VL - 50
ER -