BibTex format
@article{Sinharay:2017:10.1016/S0140-6736(17)32643-0,
author = {Sinharay, R and Gong, J and Barratt, B and Ohman-Strickland, P and Ernst, S and Kelly, F and Zhang, J and Collins, P and Cullinan, P and Chung, KF},
doi = {10.1016/S0140-6736(17)32643-0},
journal = {Lancet},
pages = {339--349},
title = {Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study},
url = {http://dx.doi.org/10.1016/S0140-6736(17)32643-0},
volume = {391},
year = {2017}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - BackgroundLong-term exposure to pollution can lead to an increase in the rate of decline of lung function, especially in older individuals and in those with chronic obstructive pulmonary disease (COPD), whereas shorter-term exposure at higher pollution levels has been implicated in causing excess deaths from ischaemic heart disease and exacerbations of COPD. We aimed to assess the effects on respiratory and cardiovascular responses of walking down a busy street with high levels of pollution compared with walking in a traffic-free area with lower pollution levels in older adults.MethodsIn this randomised, crossover study, we recruited men and women aged 60 years and older with angiographically proven stable ischaemic heart disease or stage 2 Global initiative for Obstructive Lung Disease (GOLD) COPD who had been clinically stable for 6 months, and age-matched healthy volunteers. Individuals with ischaemic heart disease or COPD were recruited from existing databases or outpatient respiratory and cardiology clinics at the Royal Brompton & Harefield NHS Foundation Trust and age-matched healthy volunteers using advertising and existing databases. All participants had abstained from smoking for at least 12 months and medications were taken as recommended by participants' doctors during the study. Participants were randomly assigned by drawing numbered disks at random from a bag to do a 2 h walk either along a commercial street in London (Oxford Street) or in an urban park (Hyde Park). Baseline measurements of participants were taken before the walk in the hospital laboratory. During each walk session, black carbon, particulate matter (PM) concentrations, ultrafine particles, and nitrogen dioxide (NO2) concentrations were measured.FindingsBetween October, 2012, and June, 2014, we screened 135 participants, of whom 40 healthy volunteers, 40 individuals with COPD, and 39 with ischaemic heart disease were recruited. Concentrations of black carbon, NO2, PM10, PM2.5, and ul
AU - Sinharay,R
AU - Gong,J
AU - Barratt,B
AU - Ohman-Strickland,P
AU - Ernst,S
AU - Kelly,F
AU - Zhang,J
AU - Collins,P
AU - Cullinan,P
AU - Chung,KF
DO - 10.1016/S0140-6736(17)32643-0
EP - 349
PY - 2017///
SN - 0140-6736
SP - 339
TI - Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study
T2 - Lancet
UR - http://dx.doi.org/10.1016/S0140-6736(17)32643-0
UR - http://hdl.handle.net/10044/1/51261
VL - 391
ER -