BibTex format
@article{Preston:2020:10.1016/j.chemosphere.2019.124667,
author = {Preston, GW and Dagnino, S and Ponzi, E and Sozeri, O and van, Veldhoven K and Barratt, B and Liu, S and Grigoryan, H and Lu, SS and Rappaport, SM and Chung, KF and Cullinan, P and Sinharay, R and Kelly, FJ and Chadeau-Hyam, M and Vineis, P and Phillips, DH},
doi = {10.1016/j.chemosphere.2019.124667},
journal = {Chemosphere},
title = {Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study},
url = {http://dx.doi.org/10.1016/j.chemosphere.2019.124667},
volume = {239},
year = {2020}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Exposure to air pollution can have both short-term and long-term effects on health. However, the relationships between specific pollutants and their effects can be obscured by characteristics of both the pollution and the exposed population. One way of elucidating the relationships is to link exposures and internal changes at the level of the individual. To this end, we combined personal exposure monitoring (59 individuals, Oxford Street II crossover study) with mass-spectrometry-based analyses of putative serum albumin adducts (fixed-step selected reaction monitoring). We attempted to infer adducts' identities using data from another, higher-resolution mass spectrometry method, and were able to detect a semi-synthetic standard with both methods. A generalised least squares regression method was used to test for associations between amounts of adducts and pollution measures (ambient concentrations of nitrogen dioxide and particulate matter), and between amounts of adducts and short-term health outcomes (measures of lung health and arterial stiffness). Amounts of some putative adducts (e.g., one with a positive mass shift of approximately 143Da) were associated with exposure to pollution (11 associations), and amounts of other adducts were associated with health outcomes (eight associations). Adducts did not appear to provide a link between exposures and short-term health outcomes.
AU - Preston,GW
AU - Dagnino,S
AU - Ponzi,E
AU - Sozeri,O
AU - van,Veldhoven K
AU - Barratt,B
AU - Liu,S
AU - Grigoryan,H
AU - Lu,SS
AU - Rappaport,SM
AU - Chung,KF
AU - Cullinan,P
AU - Sinharay,R
AU - Kelly,FJ
AU - Chadeau-Hyam,M
AU - Vineis,P
AU - Phillips,DH
DO - 10.1016/j.chemosphere.2019.124667
PY - 2020///
SN - 1879-1298
TI - Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover study
T2 - Chemosphere
UR - http://dx.doi.org/10.1016/j.chemosphere.2019.124667
UR - https://www.ncbi.nlm.nih.gov/pubmed/31499299
UR - http://hdl.handle.net/10044/1/74531
VL - 239
ER -