In this section
@article{Sharanya:2019:10.1177/1479973119843650,
author = {Sharanya, A and Ciano, M and Withana, S and Polkey, M and Kemp, P and Natanek, S},
doi = {10.1177/1479973119843650},
journal = {Chronic Respiratory Disease},
pages = {1--13},
title = {Sex differences in COPD-related quadriceps muscle dysfunction and fibre abnormalities},
url = {http://dx.doi.org/10.1177/1479973119843650},
volume = {16},
year = {2019}
}
TY - JOUR
AB - Background: In COPD, lower limb dysfunction is associated with reduced exercise capacity, increased hospitalisations and mortality. We investigated sex differences in the prevalence of quadriceps dysfunction and fibre abnormalities in a large COPD cohort, controlling for the normal sex differences in health. Methods: We compared existing data from 76 male and 38 female COPD patients where each variable was expressed as a function of gender-specific normal values (obtained from 16 male and 14 female controls). Results: Female COPD patients had lower quadriceps muscle strength and peak workload on a maximal incremental cycle ergometry protocol compared to male patients. Female patients had a smaller type II fibre cross-sectional area (CSA) compared to male patients, suggesting a greater female preponderance to fibre atrophy, although this result was largely driven by a few male patients with increased type II fibre CSA. Female patients had significantly higher concentrations of a number of plasma pro-inflammatory cytokines including tumor necrosis factor alpha (TNFα) and interleukin 8 (IL8), but not lower levels of physical activity or arterial oxygenation, compared to males. Conclusions: Our data confirms results from a previous small study and suggests that female COPD patients have a greater prevalence of muscle wasting and weakness. Larger studies investigating sex differences in COPD-related muscle atrophy and weakness are needed, as the results will have implications for monitoring in clinical practice and for design of clinical trials evaluating novel muscle anabolic agents.
AU - Sharanya,A
AU - Ciano,M
AU - Withana,S
AU - Polkey,M
AU - Kemp,P
AU - Natanek,S
DO - 10.1177/1479973119843650
EP - 13
PY - 2019///
SN - 1479-9723
SP - 1
TI - Sex differences in COPD-related quadriceps muscle dysfunction and fibre abnormalities
T2 - Chronic Respiratory Disease
UR - http://dx.doi.org/10.1177/1479973119843650
UR - https://journals.sagepub.com/doi/10.1177/1479973119843650#
UR - http://hdl.handle.net/10044/1/68707
VL - 16
ER -