BibTex format
@article{Hersh:2019:10.1513/AnnalsATS.201810-716WS,
author = {Hersh, CP and Adcock, IM and Celedon, JC and Cho, MH and Christiani, DC and Himes, BE and Kaminski, N and Mathias, RA and Meyers, DA and Quackenbush, J and Redline, S and Steiling, KA and Tabor, HK and Tobin, MD and Wurfel, MM and Yang, IV and Koppelman, GH},
doi = {10.1513/AnnalsATS.201810-716WS},
journal = {Annals of the American Thoracic Society},
pages = {1--16},
title = {High-throughput sequencing in respiratory, critical care, and sleep medicine research. An Official American Thoracic Society Workshop Report},
url = {http://dx.doi.org/10.1513/AnnalsATS.201810-716WS},
volume = {16},
year = {2019}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - High-throughput, “next-generation” sequencing methods are now being broadly applied across all fields of biomedical research, including respiratory disease, critical care, and sleep medicine. Although there are numerous review articles and best practice guidelines related to sequencing methods and data analysis, there are fewer resources summarizing issues related to study design and interpretation, especially as applied to common, complex, nonmalignant diseases. To address these gaps, a single-day workshop was held at the American Thoracic Society meeting in May 2017, led by the American Thoracic Society Section on Genetics and Genomics. The aim of this workshop was to review the design, analysis, interpretation, and functional follow-up of high-throughput sequencing studies in respiratory, critical care, and sleep medicine research. This workshop brought together experts in multiple fields, including genetic epidemiology, biobanking, bioinformatics, and research ethics, along with physician-scientists with expertise in a range of relevant diseases. The workshop focused on application of DNA and RNA sequencing research in common chronic diseases and did not cover sequencing studies in lung cancer, monogenic diseases (e.g., cystic fibrosis), or microbiome sequencing. Participants reviewed and discussed study design, data analysis and presentation, interpretation, functional follow-up, and reporting of results. This report summarizes the main conclusions of the workshop, specifically addressing the application of these methods in respiratory, critical care, and sleep medicine research. This workshop report may serve as a resource for our research community as well as for journal editors and reviewers of sequencing-based manuscript submissions in our research field.
AU - Hersh,CP
AU - Adcock,IM
AU - Celedon,JC
AU - Cho,MH
AU - Christiani,DC
AU - Himes,BE
AU - Kaminski,N
AU - Mathias,RA
AU - Meyers,DA
AU - Quackenbush,J
AU - Redline,S
AU - Steiling,KA
AU - Tabor,HK
AU - Tobin,MD
AU - Wurfel,MM
AU - Yang,IV
AU - Koppelman,GH
DO - 10.1513/AnnalsATS.201810-716WS
EP - 16
PY - 2019///
SN - 2329-6933
SP - 1
TI - High-throughput sequencing in respiratory, critical care, and sleep medicine research. An Official American Thoracic Society Workshop Report
T2 - Annals of the American Thoracic Society
UR - http://dx.doi.org/10.1513/AnnalsATS.201810-716WS
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000454507300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/67691
VL - 16
ER -