BibTex format
@article{Kojodjojo:2010:10.1136/hrt.2009.192419,
author = {Kojodjojo, P and O'Neill, MD and Lim, PB and Malcolm-Lawes, L and Whinnett, ZI and Salukhe, TV and Linton, NW and Lefroy, D and Mason, A and Wright, I and Peters, NS and Kanagaratnam, P and Davies, DW},
doi = {10.1136/hrt.2009.192419},
journal = {Heart},
pages = {1379--1384},
title = {Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablation},
url = {http://dx.doi.org/10.1136/hrt.2009.192419},
volume = {96},
year = {2010}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Background To prevent atrial fibrillation (AF) recurrenceafter catheter ablation, pulmonary venous isolation (PVI)at an antral level is more effective than segmental ostialablation. Cryoablation around the pulmonary venous (PV)ostia for AF therapy is potentially safer compared toradiofrequency ablation (RFA). The aim of this study wasto investigate the efficacy of a strategy using a largecryoablation balloon to perform antral cryoablation with‘touch-up’ ostial cryoablation for PVI in patients withparoxysmal and persistent AF.Methods Paroxysmal and persistent AF patientsundergoing their first left atrial ablation were recruited.After cryoballoon therapy, each PV was assessed forisolation and if necessary, treated with focal ostialcryoablation until PVI was achieved. Follow-up withHolter monitoring was performed. Clinical outcomes ofthe cryoablation protocol were compared, withconsecutive patients undergoing PVI by RFA.Results 124 consecutive patients underwentcryoablation. 77% of paroxysmal and 48% of persistentAF subjects were free from AF at 12 months aftera single procedure. Over the same time period, 53consecutive paroxysmal AF subjects underwent PVI withRFA and at 12 months, 72% were free from AF at12 months (p¼NS). There were too few persistent AFsubjects (n¼8) undergoing solely PVI by RFA asa comparison group. Procedural and fluoroscopic timesduring cryoablation were significantly shorter than RFA.Conclusions PV isolation can be achieved in less than2 h by a simple cryoablation protocol with excellentresults after a single intervention, particularly forparoxysmal AF.
AU - Kojodjojo,P
AU - O'Neill,MD
AU - Lim,PB
AU - Malcolm-Lawes,L
AU - Whinnett,ZI
AU - Salukhe,TV
AU - Linton,NW
AU - Lefroy,D
AU - Mason,A
AU - Wright,I
AU - Peters,NS
AU - Kanagaratnam,P
AU - Davies,DW
DO - 10.1136/hrt.2009.192419
EP - 1384
PY - 2010///
SN - 1468-201X
SP - 1379
TI - Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non-randomised comparison with pulmonary venous isolation by radiofrequency ablation
T2 - Heart
UR - http://dx.doi.org/10.1136/hrt.2009.192419
UR - http://hdl.handle.net/10044/1/24486
VL - 96
ER -