BibTex format
@article{Dreier:2016:10.1177/0271678X16654496,
author = {Dreier, JP and Fabricius, M and Ayata, C and Sakowitz, OW and William, Shuttleworth C and Dohmen, C and Graf, R and Vajkoczy, P and Helbok, R and Suzuki, M and Schiefecker, AJ and Major, S and Winkler, MK and Kang, EJ and Milakara, D and Oliveira-Ferreira, AI and Reiffurth, C and Revankar, GS and Sugimoto, K and Dengler, NF and Hecht, N and Foreman, B and Feyen, B and Kondziella, D and Friberg, CK and Piilgaard, H and Rosenthal, ES and Westover, MB and Maslarova, A and Santos, E and Hertle, D and Sánchez-Porras, R and Jewell, SL and Balança, B and Platz, J and Hinzman, JM and Lückl, J and Schoknecht, K and Schöll, M and Drenckhahn, C and Feuerstein, D and Eriksen, N and Horst, V and Bretz, JS and Jahnke, P and Scheel, M and Bohner, G and Rostrup, E and Pakkenberg, B and Heinemann, U and Claassen, J and Carlson, AP and Kowoll, CM and Lublinsky, S and Chassidim, Y and Shelef, I and Friedman, A and Brinker, G and Reiner, M and Kirov, SA and Andrew, RD and Farkas, E and Güresir, E and Vatt},
doi = {10.1177/0271678X16654496},
journal = {Journal of Cerebral Blood Flow & Metabolism},
title = {Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group.},
url = {http://dx.doi.org/10.1177/0271678X16654496},
year = {2016}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic disruption of viable cerebral gray matter, and are a crucial mechanism of lesion development. Spreading depolarizations are increasingly recorded during multimodal neuromonitoring in neurocritical care as a causal biomarker providing a diagnostic summary measure of metabolic failure and excitotoxic injury. Focal ischemia causes spreading depolarization within minutes. Further spreading depolarizations arise for hours to days due to energy supply-demand mismatch in viable tissue. Spreading depolarizations exacerbate neuronal injury through prolonged ionic breakdown and spreading depolarization-related hypoperfusion (spreading ischemia). Local duration of the depolarization indicates local tissue energy status and risk of injury. Regional electrocorticographic monitoring affords even remote detection of injury because spreading depolarizations propagate widely from ischemic or metabolically stressed zones; characteristic patterns, including temporal clusters of spreading depolarizations and persistent depression of spontaneous cortical activity, can be recognized and quantified. Here, we describe the experimental basis for interpreting these patterns and illustrate their translation to human disease. We further provide consensus recommendations for electrocorticographic methods to record, classify, and score spreading depolarizations and associated spreading depressions. These methods offer distinct advantages over other neuromonitoring modalities and allow for future refinement through less invasive and more automated approaches.
AU - Dreier,JP
AU - Fabricius,M
AU - Ayata,C
AU - Sakowitz,OW
AU - William,Shuttleworth C
AU - Dohmen,C
AU - Graf,R
AU - Vajkoczy,P
AU - Helbok,R
AU - Suzuki,M
AU - Schiefecker,AJ
AU - Major,S
AU - Winkler,MK
AU - Kang,EJ
AU - Milakara,D
AU - Oliveira-Ferreira,AI
AU - Reiffurth,C
AU - Revankar,GS
AU - Sugimoto,K
AU - Dengler,NF
AU - Hecht,N
AU - Foreman,B
AU - Feyen,B
AU - Kondziella,D
AU - Friberg,CK
AU - Piilgaard,H
AU - Rosenthal,ES
AU - Westover,MB
AU - Maslarova,A
AU - Santos,E
AU - Hertle,D
AU - Sánchez-Porras,R
AU - Jewell,SL
AU - Balança,B
AU - Platz,J
AU - Hinzman,JM
AU - Lückl,J
AU - Schoknecht,K
AU - Schöll,M
AU - Drenckhahn,C
AU - Feuerstein,D
AU - Eriksen,N
AU - Horst,V
AU - Bretz,JS
AU - Jahnke,P
AU - Scheel,M
AU - Bohner,G
AU - Rostrup,E
AU - Pakkenberg,B
AU - Heinemann,U
AU - Claassen,J
AU - Carlson,AP
AU - Kowoll,CM
AU - Lublinsky,S
AU - Chassidim,Y
AU - Shelef,I
AU - Friedman,A
AU - Brinker,G
AU - Reiner,M
AU - Kirov,SA
AU - Andrew,RD
AU - Farkas,E
AU - Güresir,E
AU - Vatter,H
AU - Chung,LS
AU - Brennan,KC
AU - Lieutaud,T
AU - Marinesco,S
AU - Maas,AI
AU - Sahuquillo,J
AU - Dahlem,MA
AU - Richter,F
AU - Herreras,O
AU - Boutelle,MG
AU - Okonkwo,DO
AU - Bullock,MR
AU - Witte,OW
AU - Martus,P
AU - van,den Maagdenberg AM
AU - Ferrari,MD
AU - Dijkhuizen,RM
AU - Shutter,LA
AU - Andaluz,N
AU - Schulte,AP
AU - MacVicar,B
AU - Watanabe,T
AU - Woitzik,J
AU - Lauritzen,M
AU - Strong,AJ
AU - Hartings,JA
DO - 10.1177/0271678X16654496
PY - 2016///
SN - 0271-678X
TI - Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group.
T2 - Journal of Cerebral Blood Flow & Metabolism
UR - http://dx.doi.org/10.1177/0271678X16654496
ER -