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@article{Slater:2016:10.1016/j.pt.2016.09.004,
author = {Slater, HC and Okell, LC and Ghani, AC},
doi = {10.1016/j.pt.2016.09.004},
journal = {Trends in Parasitology},
pages = {175--184},
title = {Mathematical Modelling to Guide Drug Development for Malaria Elimination},
url = {http://dx.doi.org/10.1016/j.pt.2016.09.004},
volume = {33},
year = {2016}
}
TY - JOUR
AB - Mathematical models of the dynamics of a drug within the host are now frequently used to guide drug development. These generally focus on assessing the efficacy and duration of response to guide patient therapy. Increasingly, antimalarial drugs are used at the population level, to clear infections, provide chemoprevention, and to reduce onward transmission of infection. However, there is less clarity on the extent to which different drug properties are important for these different uses. In addition, the emergence of drug resistance poses new threats to longer-term use and highlights the need for rational drug development. Here, we argue that integrating within-host pharmacokinetic and pharmacodynamic (PK/PD) models with mathematical models for the population-level transmission of malaria is key to guiding optimal drug design to aid malaria elimination.
AU - Slater,HC
AU - Okell,LC
AU - Ghani,AC
DO - 10.1016/j.pt.2016.09.004
EP - 184
PY - 2016///
SN - 1471-5007
SP - 175
TI - Mathematical Modelling to Guide Drug Development for Malaria Elimination
T2 - Trends in Parasitology
UR - http://dx.doi.org/10.1016/j.pt.2016.09.004
UR - http://hdl.handle.net/10044/1/41556
VL - 33
ER -
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