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@article{Wong:2014:10.7554/eLife.03080,
author = {Wong, W and Bai, X-C and Brown, A and Fernandez, IS and Hanssen, E and Condron, M and Tan, YH and Baum, J and Scheres, SHW},
doi = {10.7554/eLife.03080},
journal = {eLife},
pages = {1--20},
title = {Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine},
url = {http://dx.doi.org/10.7554/eLife.03080},
volume = {3},
year = {2014}
}
TY - JOUR
AB - Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies. Antibiotics that inhibit protein translation are promising candidates for repositioning. We have solved the cryo-EM structure of the cytoplasmic ribosome from the human malaria parasite, Plasmodium falciparum, in complex with emetine at 3.2 Å resolution. Emetine is an anti-protozoan drug used in the treatment of ameobiasis that also displays potent anti-malarial activity. Emetine interacts with the E-site of the ribosomal small subunit and shares a similar binding site with the antibiotic pactamycin, thereby delivering its therapeutic effect by blocking mRNA/tRNA translocation. As the first cryo-EM structure that visualizes an antibiotic bound to any ribosome at atomic resolution, this establishes cryo-EM as a powerful tool for screening and guiding the design of drugs that target parasite translation machinery.
AU - Wong,W
AU - Bai,X-C
AU - Brown,A
AU - Fernandez,IS
AU - Hanssen,E
AU - Condron,M
AU - Tan,YH
AU - Baum,J
AU - Scheres,SHW
DO - 10.7554/eLife.03080
EP - 20
PY - 2014///
SN - 2050-084X
SP - 1
TI - Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine
T2 - eLife
UR - http://dx.doi.org/10.7554/eLife.03080
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000338716500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - https://elifesciences.org/articles/03080
VL - 3
ER -
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