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@article{Marshall:2013:10.1186/1475-2875-12-291,
author = {Marshall, JM and White, MT and Ghani, AC and Schlein, Y and Muller, GC and Beier, JC},
doi = {10.1186/1475-2875-12-291},
journal = {Malaria Journal},
title = {Quantifying the mosquito's sweet tooth: modelling the effectiveness of attractive toxic sugar baits (ATSB) for malaria vector control},
url = {http://dx.doi.org/10.1186/1475-2875-12-291},
volume = {12},
year = {2013}
}
TY - JOUR
AB - Background: Current vector control strategies focus largely on indoor measures, such as long-lasting insecticidetreated nets (LLINs) and indoor residual spraying (IRS); however mosquitoes frequently feed on sugar sourcesoutdoors, inviting the possibility of novel control strategies. Attractive toxic sugar baits (ATSB), either sprayed onvegetation or provided in outdoor bait stations, have been shown to significantly reduce mosquito densities inthese settings.Methods: Simple models of mosquito sugar-feeding behaviour were fitted to data from an ATSB field trial in Maliand used to estimate sugar-feeding rates and the potential of ATSB to control mosquito populations. The modeland fitted parameters were then incorporated into a larger integrated vector management (IVM) model to assessthe potential contribution of ATSB to future IVM programmes.Results: In the Mali experimental setting, the model suggests that about half of female mosquitoes fed on ATSBsolution per day, dying within several hours of ingesting the toxin. Using a model incorporating the number ofgonotrophic cycles completed by female mosquitoes, a higher sugar-feeding rate was estimated for youngermosquitoes than for older mosquitoes. Extending this model to incorporate other vector control interventionssuggests that an IVM programme based on both ATSB and LLINs may substantially reduce mosquito density andsurvival rates in this setting, thereby substantially reducing parasite transmission. This is predicted to exceed theimpact of LLINs in combination with IRS provided ATSB feeding rates are 50% or more of Mali experimental levels.In addition, ATSB is predicted to be particularly effective against Anopheles arabiensis, which is relatively exophilicand therefore less affected by IRS and LLINs.Conclusions: These results suggest that high coverage with a combination of LLINs and ATSB could result insubstantial reductions in malaria transmission in this setting. Further field studies of ATSB in other settings
AU - Marshall,JM
AU - White,MT
AU - Ghani,AC
AU - Schlein,Y
AU - Muller,GC
AU - Beier,JC
DO - 10.1186/1475-2875-12-291
PY - 2013///
SN - 1475-2875
TI - Quantifying the mosquito's sweet tooth: modelling the effectiveness of attractive toxic sugar baits (ATSB) for malaria vector control
T2 - Malaria Journal
UR - http://dx.doi.org/10.1186/1475-2875-12-291
UR - http://hdl.handle.net/10044/1/30721
VL - 12
ER -
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