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@article{Rees:2023:10.1136/bmjpo-2022-001810,
author = {Rees, P and Callan, C and Chadda, K and Vaal, M and Diviney, J and Sabti, S and Harnden, F and Gardiner, J and Battersby, C and Gale, C and Sutcliffe, A},
doi = {10.1136/bmjpo-2022-001810},
journal = {BMJ Paediatrics Open},
pages = {1--14},
title = {School-age outcomes of children after perinatal brain injury: a systematic review and meta-analysis},
url = {http://dx.doi.org/10.1136/bmjpo-2022-001810},
volume = {7},
year = {2023}
}

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TY  - JOUR
AB  - Background Over 3000 children suffer a perinatal brain injury in England every year according to national surveillance. The childhood outcomes of infants with perinatal brain injury are however unknown.Methods A systematic review and meta-analyses were undertaken of studies published between 2000 and September 2021 exploring school-aged neurodevelopmental outcomes of children after perinatal brain injury compared with those without perinatal brain injury. The primary outcome was neurodevelopmental impairment, which included cognitive, motor, speech and language, behavioural, hearing or visual impairment after 5 years of age.Results This review included 42 studies. Preterm infants with intraventricular haemorrhage (IVH) grades 3–4 were found to have a threefold greater risk of moderate-to-severe neurodevelopmental impairment at school age OR 3.69 (95% CI 1.7 to 7.98) compared with preterm infants without IVH. Infants with perinatal stroke had an increased incidence of hemiplegia 61% (95% CI 39.2% to 82.9%) and an increased risk of cognitive impairment (difference in full scale IQ −24.2 (95% CI –30.73 to –17.67) . Perinatal stroke was also associated with poorer academic performance; and lower mean receptive −20.88 (95% CI –36.66 to –5.11) and expressive language scores −20.25 (95% CI –34.36 to –6.13) on the Clinical Evaluation of Language Fundamentals (CELF) assessment. Studies reported an increased risk of persisting neurodevelopmental impairment at school age after neonatal meningitis. Cognitive impairment and special educational needs were highlighted after moderate-to-severe hypoxic-ischaemic encephalopathy. However, there were limited comparative studies providing school-aged outcome data across neurodevelopmental domains and few provided adjusted data. Findings were further limited by the heterogeneity of studies.Conclusions Longitudinal population studies exploring childhood outcomes after perinatal b
AU  - Rees,P
AU  - Callan,C
AU  - Chadda,K
AU  - Vaal,M
AU  - Diviney,J
AU  - Sabti,S
AU  - Harnden,F
AU  - Gardiner,J
AU  - Battersby,C
AU  - Gale,C
AU  - Sutcliffe,A
DO  - 10.1136/bmjpo-2022-001810
EP  - 14
PY  - 2023///
SN  - 2399-9772
SP  - 1
TI  - School-age outcomes of children after perinatal brain injury: a systematic review and meta-analysis
T2  - BMJ Paediatrics Open
UR  - http://dx.doi.org/10.1136/bmjpo-2022-001810
UR  - https://bmjpaedsopen.bmj.com/content/7/1/e001810
UR  - http://hdl.handle.net/10044/1/104786
VL  - 7
ER  -

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