BibTex format
@article{Smith:2023:10.1136/bmjgh-2022-009495,
author = {Smith, ER and Oakley, E and Grandner, GW and Ferguson, K and Farooq, F and Afshar, Y and Ahlberg, M and Ahmadzia, H and Akelo, V and Aldrovandi, G and Barr, BAT and Bevilacqua, E and Brandt, JS and Broutet, N and Buhigas, IF and Carrillo, J and Clifton, R and Conry, J and Cosmi, E and Crispi, F and Crovetto, F and Delgado-Lopez, C and Divakar, H and Driscoll, AJ and Favre, G and Flaherman, VJ and Gale, C and Gil, MM and Gottlieb, SL and Gratacos, E and Hernandez, O and Jones, S and Kalafat, E and Khagayi, S and Knight, M and Kotloff, K and Lanzone, A and Le, Doare K and Lees, C and Litman, E and Lokken, EM and Laurita, Longo V and Madhi, SA and Magee, LA and Martinez-Portilla, RJ and McClure, EM and Metz, TD and Miller, ES and Money, D and Moungmaithong, S and Mullins, E and Nachega, JB and Nunes, MC and Onyango, D and Panchaud, A and Poon, LC and Raiten, D and Regan, L and Rukundo, G and Sahota, D and Sakowicz, A and Sanin-Blair, J and Soderling, J and Stephansson, O and Temmerman, M },
doi = {10.1136/bmjgh-2022-009495},
journal = {BMJ Global Health},
pages = {1--19},
title = {Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis},
url = {http://dx.doi.org/10.1136/bmjgh-2022-009495},
volume = {8},
year = {2023}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Introduction Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.Methods We screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.Results We screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.Conclusions This analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth r
AU - Smith,ER
AU - Oakley,E
AU - Grandner,GW
AU - Ferguson,K
AU - Farooq,F
AU - Afshar,Y
AU - Ahlberg,M
AU - Ahmadzia,H
AU - Akelo,V
AU - Aldrovandi,G
AU - Barr,BAT
AU - Bevilacqua,E
AU - Brandt,JS
AU - Broutet,N
AU - Buhigas,IF
AU - Carrillo,J
AU - Clifton,R
AU - Conry,J
AU - Cosmi,E
AU - Crispi,F
AU - Crovetto,F
AU - Delgado-Lopez,C
AU - Divakar,H
AU - Driscoll,AJ
AU - Favre,G
AU - Flaherman,VJ
AU - Gale,C
AU - Gil,MM
AU - Gottlieb,SL
AU - Gratacos,E
AU - Hernandez,O
AU - Jones,S
AU - Kalafat,E
AU - Khagayi,S
AU - Knight,M
AU - Kotloff,K
AU - Lanzone,A
AU - Le,Doare K
AU - Lees,C
AU - Litman,E
AU - Lokken,EM
AU - Laurita,Longo V
AU - Madhi,SA
AU - Magee,LA
AU - Martinez-Portilla,RJ
AU - McClure,EM
AU - Metz,TD
AU - Miller,ES
AU - Money,D
AU - Moungmaithong,S
AU - Mullins,E
AU - Nachega,JB
AU - Nunes,MC
AU - Onyango,D
AU - Panchaud,A
AU - Poon,LC
AU - Raiten,D
AU - Regan,L
AU - Rukundo,G
AU - Sahota,D
AU - Sakowicz,A
AU - Sanin-Blair,J
AU - Soderling,J
AU - Stephansson,O
AU - Temmerman,M
AU - Thorson,A
AU - Tolosa,JE
AU - Townson,J
AU - Valencia-Prado,M
AU - Visentin,S
AU - von,Dadelszen P
AU - Waldorf,KA
AU - Whitehead,C
AU - Yassa,M
AU - Tielsch,JM
DO - 10.1136/bmjgh-2022-009495
EP - 19
PY - 2023///
SN - 2059-7908
SP - 1
TI - Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis
T2 - BMJ Global Health
UR - http://dx.doi.org/10.1136/bmjgh-2022-009495
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000926228300001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR - https://gh.bmj.com/content/8/1/e009495
UR - http://hdl.handle.net/10044/1/104684
VL - 8
ER -
